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- W749062375 abstract "Multiple recent studies showed that anemia is a common complication of malignant tumors, especially during chemotherapy. Reduced hemoglobin blood levels are manifested as weakness and decreased tolerance for physical and mental activities with resulting deterioration in quality of life. In addition, anemia is associated with decreased survival of cancer patients. Cancer-related anemia can be caused by, among others, secretion of cytokines which affect various stages of erythropoiesis in the bone marrow, the life-span of red blood cells, and iron metabolism. Administration of erythropoietins for anemia in cancer patients results in improved Hb levels and the reduced need for transfusions, but it increases the risk of thrombosis. Enhanced pro-inflammatory cytokine secretion in cancer patients reduces bioavailability of iron required for effective erythropoiesis. This review summarizes clinical consequences of iron deficiency and anemia in cancer patients and includes discussion of the mechanisms of impaired iron metabolism, its diagnosis, and management. The data from clinical studies evaluating efficacy of various iron supplementations alone or combined with erythropoietins are presented." @default.
- W749062375 created "2016-06-24" @default.
- W749062375 creator A5071809163 @default.
- W749062375 date "2013-01-01" @default.
- W749062375 modified "2023-09-24" @default.
- W749062375 title "Анемии и дефицит железа у онкологических больных" @default.
- W749062375 hasPublicationYear "2013" @default.
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