FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W7491050> ?p ?o ?g. }

• W7491050 endingPage "228" @default.
• W7491050 startingPage "191" @default.
• W7491050 abstract "Despite improvements in medical and surgical therapy, myocardial infarction or nonischemic heart disease is often the beginning of a downward spiral leading to congestive heart failure. Other than heart transplantation or implantation of a ventricular assist device “artificial heart,” current therapies merely help the organism to survive with a heart that is working at a fraction of its original capacity. It is therefore no surprise that cardiac stem cell therapy, with its promise to regenerate or rejuvenate the heart, has raised many hopes. Although extensive experimental data support the concept of cardiac cell therapy, neither the ideal source nor the type of cell or the critical quantity and mode of application in the clinical setting has been defined so far. In patients with acute myocardial infarction, several cell-based approaches, such as intracoronary delivery of mononuclear bone marrow cells or enriched hematopoietic progenitor cell products; systemic cytokine stimulation with release of bone marrow progenitor cells into the systemic circulation; and both intravenous or intracoronary delivery of allogenic mesenchymal stem cells, are currently being tested. There are encouraging data for each of these strategies based on small cohorts, but the results regarding recovery of function are ambiguous. For treatment of patients with chronic heart failure, other approaches, such as catheter-based intramyocardial delivery of various cell types and surgical implantation of bone marrow or blood-derived cells in conjunction with bypass surgery or as surgical stand-alone procedures, are being evaluated. Moreover, skeletal muscle-derived myoblasts have been used with various delivery techniques. Again, a number of controlled trials have produced conflicting results, and multicenter studies are currently being conducted. Currently, more advanced forms of cardiac cell therapy are attracting a lot of attention, including genetic cell engineering, coimplantation of specific extracellular matrix components, preclinical testing of embryonic stem cell–derived cells, as well as imaging techniques for in situ cell tracking and imaging of cell function. Prior to clinical routine use, however, numerous technical, medical, and regulatory obstacles will have to be overcome. Here we will briefly summarize the basic research background of cardiac regenerative medicine and will attempt a critical appraisal of the current efforts to translate the experimental approaches into the clinical setting." @default.
• W7491050 created "2016-06-24" @default.
• W7491050 creator A5069162200 @default.
• W7491050 creator A5072408501 @default.
• W7491050 creator A5088568884 @default.
• W7491050 date "2009-01-01" @default.
• W7491050 modified "2023-09-27" @default.
• W7491050 title "Clinical Cell Therapy for Heart Disease" @default.
• W7491050 cites W1542955217 @default.
• W7491050 cites W1569560733 @default.
• W7491050 cites W1599022641 @default.
• W7491050 cites W1631250427 @default.
• W7491050 cites W189185435 @default.
• W7491050 cites W1963756072 @default.
• W7491050 cites W1965953554 @default.
• W7491050 cites W1966184440 @default.
• W7491050 cites W1969095342 @default.
• W7491050 cites W1970661970 @default.
• W7491050 cites W1974864607 @default.
• W7491050 cites W1975417724 @default.
• W7491050 cites W1976127975 @default.
• W7491050 cites W1977437881 @default.
• W7491050 cites W1977872287 @default.
• W7491050 cites W1979608640 @default.
• W7491050 cites W1986522836 @default.
• W7491050 cites W1988488411 @default.
• W7491050 cites W1994344017 @default.
• W7491050 cites W2002655127 @default.
• W7491050 cites W2005237823 @default.
• W7491050 cites W2006476648 @default.
• W7491050 cites W2009184449 @default.
• W7491050 cites W2010031978 @default.
• W7491050 cites W2010775796 @default.
• W7491050 cites W2012065442 @default.
• W7491050 cites W2015676407 @default.
• W7491050 cites W2015991551 @default.
• W7491050 cites W2019850506 @default.
• W7491050 cites W2021224652 @default.
• W7491050 cites W2022336190 @default.
• W7491050 cites W2023014134 @default.
• W7491050 cites W2026749151 @default.
• W7491050 cites W2027134089 @default.
• W7491050 cites W2028036560 @default.
• W7491050 cites W2031812736 @default.
• W7491050 cites W2031930422 @default.
• W7491050 cites W2033042516 @default.
• W7491050 cites W2033250271 @default.
• W7491050 cites W2035040282 @default.
• W7491050 cites W2037064555 @default.
• W7491050 cites W2037639211 @default.
• W7491050 cites W2038962536 @default.
• W7491050 cites W2039420108 @default.
• W7491050 cites W2044986397 @default.
• W7491050 cites W2045443721 @default.
• W7491050 cites W2051341102 @default.
• W7491050 cites W2053767726 @default.
• W7491050 cites W2053850459 @default.
• W7491050 cites W2058195291 @default.
• W7491050 cites W2058692258 @default.
• W7491050 cites W2062238661 @default.
• W7491050 cites W2065171831 @default.
• W7491050 cites W2067591094 @default.
• W7491050 cites W2069138845 @default.
• W7491050 cites W2071746224 @default.
• W7491050 cites W2072740783 @default.
• W7491050 cites W2074456933 @default.
• W7491050 cites W2075344844 @default.
• W7491050 cites W2080539468 @default.
• W7491050 cites W2081617895 @default.
• W7491050 cites W2081678513 @default.
• W7491050 cites W2084844736 @default.
• W7491050 cites W2085350659 @default.
• W7491050 cites W2085682326 @default.
• W7491050 cites W2085846063 @default.
• W7491050 cites W2090041902 @default.
• W7491050 cites W2091395040 @default.
• W7491050 cites W2093540365 @default.
• W7491050 cites W2094457676 @default.
• W7491050 cites W2095434187 @default.
• W7491050 cites W2095666785 @default.
• W7491050 cites W2096076325 @default.
• W7491050 cites W2098234683 @default.
• W7491050 cites W2099995765 @default.
• W7491050 cites W2101995250 @default.
• W7491050 cites W2102619901 @default.
• W7491050 cites W2102824270 @default.
• W7491050 cites W2103820630 @default.
• W7491050 cites W2104978512 @default.
• W7491050 cites W2105956218 @default.
• W7491050 cites W2106673834 @default.
• W7491050 cites W2107527168 @default.
• W7491050 cites W2107851152 @default.
• W7491050 cites W2108285596 @default.
• W7491050 cites W2110667326 @default.
• W7491050 cites W2111486034 @default.
• W7491050 cites W2113074426 @default.
• W7491050 cites W2117363477 @default.
• W7491050 cites W2119161500 @default.

• next