FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W749408911> ?p ?o ?g. }

• W749408911 endingPage "322" @default.
• W749408911 startingPage "315" @default.
• W749408911 abstract "Despite therapeutic hypothermia, neonates with encephalopathy (NE) have high rates of death or disability. Darbepoetin alfa (Darbe) has comparable biological activity to erythropoietin, but has extended circulating half-life (t(1/2)). Our aim was to determine Darbe safety and pharmacokinetics as adjunctive therapy to hypothermia.Thirty infants (n = 10/arm) ≥36 wk gestation undergoing therapeutic hypothermia for NE were randomized to receive placebo, Darbe low dose (2 μg/kg), or high dose (10 μg/kg) given intravenously within 12 h of birth (first dose/hypothermia condition) and at 7 d (second dose/normothermia condition). Adverse events were documented for 1 mo. Serum samples were obtained to characterize Darbe pharmacokinetics.Adverse events (hypotension, altered liver and renal function, seizures, and death) were similar to placebo and historical controls. Following the first Darbe dose at 2 and 10 μg/kg, t(1/2) was 24 and 32 h, and the area under the curve (AUC(inf)) was 26,555 and 180,886 h*mU/ml*, respectively. In addition, clearance was not significantly different between the doses (0.05 and 0.04 l/h). At 7 d, t(1/2) was 26 and 35 h, and AUC(inf) was 10,790 and 56,233 h*mU/ml*, respectively (*P < 0.01).Darbe combined with hypothermia has similar safety profile to placebo with pharmacokinetics sufficient for weekly administration." @default.
• W749408911 created "2016-06-24" @default.
• W749408911 creator A5003535896 @default.
• W749408911 creator A5003801525 @default.
• W749408911 creator A5006624064 @default.
• W749408911 creator A5013099226 @default.
• W749408911 creator A5013863197 @default.
• W749408911 creator A5020515788 @default.
• W749408911 creator A5026854749 @default.
• W749408911 creator A5030468874 @default.
• W749408911 creator A5041051682 @default.
• W749408911 creator A5052752136 @default.
• W749408911 creator A5052769969 @default.
• W749408911 creator A5052819935 @default.
• W749408911 creator A5058654274 @default.
• W749408911 creator A5063711198 @default.
• W749408911 creator A5073610141 @default.
• W749408911 creator A5086531383 @default.
• W749408911 date "2015-05-21" @default.
• W749408911 modified "2023-09-26" @default.
• W749408911 title "Darbepoetin administration to neonates undergoing cooling for encephalopathy: a safety and pharmacokinetic trial" @default.
• W749408911 cites W1848812419 @default.
• W749408911 cites W1875919636 @default.
• W749408911 cites W1964818405 @default.
• W749408911 cites W1967501877 @default.
• W749408911 cites W1969951251 @default.
• W749408911 cites W1970325360 @default.
• W749408911 cites W1973178224 @default.
• W749408911 cites W1984478703 @default.
• W749408911 cites W1994317582 @default.
• W749408911 cites W2007690362 @default.
• W749408911 cites W2013412830 @default.
• W749408911 cites W2020591797 @default.
• W749408911 cites W2026113882 @default.
• W749408911 cites W2032426543 @default.
• W749408911 cites W2032947046 @default.
• W749408911 cites W2036518295 @default.
• W749408911 cites W2042367750 @default.
• W749408911 cites W2046529212 @default.
• W749408911 cites W2049722015 @default.
• W749408911 cites W2056601565 @default.
• W749408911 cites W2060887306 @default.
• W749408911 cites W2068423530 @default.
• W749408911 cites W2095473686 @default.
• W749408911 cites W2108511043 @default.
• W749408911 cites W2109912660 @default.
• W749408911 cites W2110230188 @default.
• W749408911 cites W2120231263 @default.
• W749408911 cites W2123266686 @default.
• W749408911 cites W2139878559 @default.
• W749408911 cites W2140607170 @default.
• W749408911 cites W2150069228 @default.
• W749408911 cites W2153446990 @default.
• W749408911 cites W2162264368 @default.
• W749408911 cites W2163634814 @default.
• W749408911 cites W2164127547 @default.
• W749408911 cites W2328782968 @default.
• W749408911 doi "https://doi.org/10.1038/pr.2015.101" @default.
• W749408911 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5564328" @default.
• W749408911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25996892" @default.
• W749408911 hasPublicationYear "2015" @default.
• W749408911 type Work @default.
• W749408911 sameAs 749408911 @default.
• W749408911 citedByCount "39" @default.
• W749408911 countsByYear W7494089112015 @default.
• W749408911 countsByYear W7494089112016 @default.
• W749408911 countsByYear W7494089112017 @default.
• W749408911 countsByYear W7494089112018 @default.
• W749408911 countsByYear W7494089112019 @default.
• W749408911 countsByYear W7494089112020 @default.
• W749408911 countsByYear W7494089112021 @default.
• W749408911 countsByYear W7494089112022 @default.
• W749408911 countsByYear W7494089112023 @default.
• W749408911 crossrefType "journal-article" @default.
• W749408911 hasAuthorship W749408911A5003535896 @default.
• W749408911 hasAuthorship W749408911A5003801525 @default.
• W749408911 hasAuthorship W749408911A5006624064 @default.
• W749408911 hasAuthorship W749408911A5013099226 @default.
• W749408911 hasAuthorship W749408911A5013863197 @default.
• W749408911 hasAuthorship W749408911A5020515788 @default.
• W749408911 hasAuthorship W749408911A5026854749 @default.
• W749408911 hasAuthorship W749408911A5030468874 @default.
• W749408911 hasAuthorship W749408911A5041051682 @default.
• W749408911 hasAuthorship W749408911A5052752136 @default.
• W749408911 hasAuthorship W749408911A5052769969 @default.
• W749408911 hasAuthorship W749408911A5052819935 @default.
• W749408911 hasAuthorship W749408911A5058654274 @default.
• W749408911 hasAuthorship W749408911A5063711198 @default.
• W749408911 hasAuthorship W749408911A5073610141 @default.
• W749408911 hasAuthorship W749408911A5086531383 @default.
• W749408911 hasBestOaLocation W7494089111 @default.
• W749408911 hasConcept C112705442 @default.
• W749408911 hasConcept C126322002 @default.
• W749408911 hasConcept C142724271 @default.
• W749408911 hasConcept C197934379 @default.
• W749408911 hasConcept C204787440 @default.
• W749408911 hasConcept C27081682 @default.
• W749408911 hasConcept C2777390192 @default.

• next