Matches in SemOpenAlex for { <https://semopenalex.org/work/W7495616> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W7495616 abstract "DNA methylation is critical in regulating gene expression and epigenetic control during the neurodevelopmental stage, which is dependent on folate availability as a methyl donor for methionine synthase. We performed this study to evaluate the effect of maternal folate status during pregnancy and lactation on the methyl status and DNA methylation in the brain and spinal cord of their 7-week old offspring. Folic acid deficiency during the gestational period caused a significant decrease in the plasma folate level, liver SAM/SAH ratio, spinal cord methionine synthase (MS) activity and DNA methylation level, and an increase in the plasma homocysteine. When folic acid was provided in the diet during either lactation or after weaning, all of the above parameters were recovered except for the DNA methylation level in the spinal cord. These results suggest that maternal folate deficiency during pregnancy affect DNA methylation level in spinal cord of the offspring, which is not fully recovered by folic acid supplementation after birth. Further study is needed to evaluate the effect of DNA hypomethylation of the spinal cord in the early developmental stage on neurologic function in the adulthood." @default.
- W7495616 created "2016-06-24" @default.
- W7495616 creator A5003315307 @default.
- W7495616 creator A5008543861 @default.
- W7495616 creator A5032388208 @default.
- W7495616 creator A5047893639 @default.
- W7495616 creator A5061300966 @default.
- W7495616 creator A5073107050 @default.
- W7495616 date "2009-04-01" @default.
- W7495616 modified "2023-09-24" @default.
- W7495616 title "Decrease of DNA methylation in spinal cord caused by maternal folate deficiency is not fully recovered by folic acid supplementation after birth" @default.
- W7495616 doi "https://doi.org/10.1096/fasebj.23.1_supplement.904.4" @default.
- W7495616 hasPublicationYear "2009" @default.
- W7495616 type Work @default.
- W7495616 sameAs 7495616 @default.
- W7495616 citedByCount "0" @default.
- W7495616 crossrefType "journal-article" @default.
- W7495616 hasAuthorship W7495616A5003315307 @default.
- W7495616 hasAuthorship W7495616A5008543861 @default.
- W7495616 hasAuthorship W7495616A5032388208 @default.
- W7495616 hasAuthorship W7495616A5047893639 @default.
- W7495616 hasAuthorship W7495616A5061300966 @default.
- W7495616 hasAuthorship W7495616A5073107050 @default.
- W7495616 hasConcept C104317684 @default.
- W7495616 hasConcept C112672928 @default.
- W7495616 hasConcept C118552586 @default.
- W7495616 hasConcept C126322002 @default.
- W7495616 hasConcept C134018914 @default.
- W7495616 hasConcept C150194340 @default.
- W7495616 hasConcept C190727270 @default.
- W7495616 hasConcept C2776659692 @default.
- W7495616 hasConcept C2777090595 @default.
- W7495616 hasConcept C2779234561 @default.
- W7495616 hasConcept C2780775167 @default.
- W7495616 hasConcept C2780912031 @default.
- W7495616 hasConcept C2780914630 @default.
- W7495616 hasConcept C33288867 @default.
- W7495616 hasConcept C41091548 @default.
- W7495616 hasConcept C515207424 @default.
- W7495616 hasConcept C54355233 @default.
- W7495616 hasConcept C552990157 @default.
- W7495616 hasConcept C55493867 @default.
- W7495616 hasConcept C71924100 @default.
- W7495616 hasConcept C86803240 @default.
- W7495616 hasConceptScore W7495616C104317684 @default.
- W7495616 hasConceptScore W7495616C112672928 @default.
- W7495616 hasConceptScore W7495616C118552586 @default.
- W7495616 hasConceptScore W7495616C126322002 @default.
- W7495616 hasConceptScore W7495616C134018914 @default.
- W7495616 hasConceptScore W7495616C150194340 @default.
- W7495616 hasConceptScore W7495616C190727270 @default.
- W7495616 hasConceptScore W7495616C2776659692 @default.
- W7495616 hasConceptScore W7495616C2777090595 @default.
- W7495616 hasConceptScore W7495616C2779234561 @default.
- W7495616 hasConceptScore W7495616C2780775167 @default.
- W7495616 hasConceptScore W7495616C2780912031 @default.
- W7495616 hasConceptScore W7495616C2780914630 @default.
- W7495616 hasConceptScore W7495616C33288867 @default.
- W7495616 hasConceptScore W7495616C41091548 @default.
- W7495616 hasConceptScore W7495616C515207424 @default.
- W7495616 hasConceptScore W7495616C54355233 @default.
- W7495616 hasConceptScore W7495616C552990157 @default.
- W7495616 hasConceptScore W7495616C55493867 @default.
- W7495616 hasConceptScore W7495616C71924100 @default.
- W7495616 hasConceptScore W7495616C86803240 @default.
- W7495616 hasIssue "S1" @default.
- W7495616 hasLocation W74956161 @default.
- W7495616 hasOpenAccess W7495616 @default.
- W7495616 hasPrimaryLocation W74956161 @default.
- W7495616 hasRelatedWork W2004424018 @default.
- W7495616 hasRelatedWork W2076203191 @default.
- W7495616 hasRelatedWork W2077978869 @default.
- W7495616 hasRelatedWork W2096534598 @default.
- W7495616 hasRelatedWork W2330971285 @default.
- W7495616 hasRelatedWork W2544107670 @default.
- W7495616 hasRelatedWork W2740214960 @default.
- W7495616 hasRelatedWork W2899730466 @default.
- W7495616 hasRelatedWork W3048737782 @default.
- W7495616 hasRelatedWork W3111017817 @default.
- W7495616 hasVolume "23" @default.
- W7495616 isParatext "false" @default.
- W7495616 isRetracted "false" @default.
- W7495616 magId "7495616" @default.
- W7495616 workType "article" @default.