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• W74964901 abstract "Research Article1 July 1990free access Oct-4: a germline-specific transcription factor mapping to the mouse t-complex. H. R. Schöler H. R. Schöler Max-Planck-Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Göttingen, FRG. Search for more papers by this author G. R. Dressler G. R. Dressler Max-Planck-Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Göttingen, FRG. Search for more papers by this author R. Balling R. Balling Max-Planck-Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Göttingen, FRG. Search for more papers by this author H. Rohdewohld H. Rohdewohld Max-Planck-Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Göttingen, FRG. Search for more papers by this author P. Gruss P. Gruss Max-Planck-Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Göttingen, FRG. Search for more papers by this author H. R. Schöler H. R. Schöler Max-Planck-Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Göttingen, FRG. Search for more papers by this author G. R. Dressler G. R. Dressler Max-Planck-Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Göttingen, FRG. Search for more papers by this author R. Balling R. Balling Max-Planck-Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Göttingen, FRG. Search for more papers by this author H. Rohdewohld H. Rohdewohld Max-Planck-Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Göttingen, FRG. Search for more papers by this author P. Gruss P. Gruss Max-Planck-Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Göttingen, FRG. Search for more papers by this author Author Information H. R. Schöler1, G. R. Dressler1, R. Balling1, H. Rohdewohld1 and P. Gruss1 1Max-Planck-Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Göttingen, FRG. The EMBO Journal (1990)9:2185-2195https://doi.org/10.1002/j.1460-2075.1990.tb07388.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Oct-4 is a maternally expressed octamer-binding protein encoded by the murine Oct-4 gene. It is present in unfertilized oocytes, but also in the inner cell mass and in primordial germ cells. Here we show that the ectopic expression of Oct-4 in HeLa cells is sufficient for transcriptional activation from the octamer motif, indicating that Oct-4 is a transcription factor. Therefore, Oct-4 is the first transcription factor described that is specific for the early stages of mouse development. The spatial and temporal expression patterns were further determined using in situ hybridization. With this technique Oct-4 expression is detected in the oocyte, in the blastocyst and before gastrulation in the embryonic ectoderm. After day 8 Oct-4 expression decreases and is restricted to primordial germ cells from about day 8.5 onwards. Therefore Oct-4 is a transcription factor that is specifically expressed in cells participating in the generation of the germline lineage. Linkage analysis using B X D recombinant inbred mouse strains demonstrates that Oct-4 maps to chromosome 17 in or near the major histocompatibility complex. Several mouse mutants in the distal region of the mouse t-complex affecting blastocyst and embryonic ectoderm formation also map to this region. Previous ArticleNext Article Volume 9Issue 71 July 1990In this issue RelatedDetailsLoading ..." @default.
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• W74964901 title "Oct-4: a germline-specific transcription factor mapping to the mouse t-complex." @default.
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• W74964901 doi "https://doi.org/10.1002/j.1460-2075.1990.tb07388.x" @default.
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