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- W749982334 endingPage "930" @default.
- W749982334 startingPage "914" @default.
- W749982334 abstract "Due to global crises such as pollution and depletion of fossil fuels, sustainable technologies based on microbial cell-factories have been garnering great interest as an alternative to chemical factories. The development of microbial cell-factories is imperative in cutting down the overall manufacturing cost. Thus, diverse metabolic engineering strategies and engineering tools have been established to obtain a preferred genotype and phenotype displaying superior productivity. However, these tools are limited to only a handful of genes with permanent modification of a genome and significant labor costs, and this is one of the bottlenecks associated with biofactory construction. Therefore, a groundbreaking rapid and high-throughput engineering tool is needed for efficient construction of microbial cell-factories. During the last decade, copious small noncoding RNAs (ncRNAs) have been discovered in bacteria. These are involved in substantial regulatory roles like transcriptional and post-transcriptional gene regulation by modulating mRNA elongation, stability, or translational efficiency. Because of their vulnerability, ncRNAs can be used as another layer of conditional control over gene expression without modifying chromosomal sequences, and hence would be a promising high-throughput tool for metabolic engineering. Here, we review successful design principles and applications of ncRNAs for high-throughput metabolic engineering or physiological studies of diverse industrially important microorganisms." @default.
- W749982334 created "2016-06-24" @default.
- W749982334 creator A5060644734 @default.
- W749982334 creator A5079271824 @default.
- W749982334 creator A5081482117 @default.
- W749982334 date "2015-11-01" @default.
- W749982334 modified "2023-10-18" @default.
- W749982334 title "Rapid and high-throughput construction of microbial cell-factories with regulatory noncoding RNAs" @default.
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