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- W750828247 abstract "The pathogenesis of vascular catheter infections has recently been extensively reviewed. This chapter summarizes existing understandings and presents details of new work published on vascular catheter infections since the recent reviews. Many factors have been shown to affect the risk of catheters becoming infected. These include the unique abilities of certain organisms, Staphylococcus epidermidis, Staphylococcus aureus, and Candida albicans, to cause catheter-related infections. Molecular typing studies increasingly are improving our understanding of the pathogenesis of S. epidermidis/CoNS catheter-related infection. Recent studies with isogenic S. epidermidis mutants increasingly suggest that production of a polysaccharide adhesin is crucial to the pathogenesis of foreign-body infection. This polysaccharide, first named PS/A, was initially described as a virulence factor in association with work examining the pathogenesis of endocarditis. Two additional findings of relevance to the pathogenesis of endocarditis and possibly vascular catheter infections are that binding to platelets facilitates endocarditis and S. aureus strains causing endocarditis are much more likely to be resistant to platelet microbicidal proteins. The pathogenesis of catheter-related thrombosis has been studied in greater depth in recent years. With peripheral catheters, ultrasonographic imaging has shown that early thrombus formation ( 24 h after insertion) occurs near the catheter tip. Recent in vitro studies have shown that surface manipulations of polyurethane can lead to differences in protein and platelet deposition with associated differences in bacterial adherence." @default.
- W750828247 created "2016-06-24" @default.
- W750828247 creator A5000124540 @default.
- W750828247 date "2014-04-30" @default.
- W750828247 modified "2023-10-02" @default.
- W750828247 title "Pathogenesis of Vascular Catheter Infection" @default.
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- W750828247 doi "https://doi.org/10.1128/9781555818067.ch6" @default.
- W750828247 hasPublicationYear "2014" @default.
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