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- W7511239 abstract "Publisher Summary This chapter describes lipid metabolism by macrophages and its relationship to atherosclerosis. There is evidence that the phospholipid that accumulates in the atherosclerotic lesion does so as a result of local synthesis in the wall rather than by filtration from the blood. Fatty acids taken up by peritoneal macrophages or by alveolar macrophages are incorporated into both phospholipid and triglyceride by these cells. The synthesis of cholesterol, phospholipid, and triglyceride by peritoneal macrophages can also be demonstrated using C 14 –labeled acetate as precursor. While it can be established that macrophages are able to synthesize a variety of lipid moieties, the problem is to decide whether this synthesis is simply an indication of metabolism in general or whether it represents a more specific function of the cell under physiological or pathological circumstances. There is evidence that macrophages may carry lipid in the blood stream and then, as lipophages, penetrate the arterial endothelium and contribute to the presence of lipid." @default.
- W7511239 created "2016-06-24" @default.
- W7511239 creator A5036721426 @default.
- W7511239 date "1967-01-01" @default.
- W7511239 modified "2023-10-18" @default.
- W7511239 title "Lipid Metabolism by Macrophages and Its Relationship to Atherosclerosis" @default.
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- W7511239 doi "https://doi.org/10.1016/b978-1-4831-9941-2.50011-x" @default.
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- W7511239 hasPublicationYear "1967" @default.
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