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- W75150274 endingPage "126" @default.
- W75150274 startingPage "117" @default.
- W75150274 abstract "Androgens are responsible for the growth of the normal prostate gland and play an essential role in the development and progression of prostate cancer. Accordingly, androgen deprivation provides a favorable initial clinical response for the majority of patients with advanced prostate cancers. However, tumors invariably recur as a lethal phenotype known as castrate-resistant disease. The androgen receptor (AR) is a nuclear transcription factor, which binds androgens in the cell cytoplasm, translocates to the nucleus, and assembles as a protein complex that regulates target gene expression. As such, the AR has been a prime target for androgen deprivation therapies. Interestingly, however, the AR maintains a critical role in the survival of castrate-resistant tumors, likely through a variety of mechanisms including receptor overexpression, mutation, splice variation, alternative ligand activation, coactivator modification, as well as the intratumoral production of androgens. Meanwhile, the impact of estrogens and the estrogen receptor in prostate cancer development and treatment continues to be defined. Here, we review current concepts regarding the role of the sex-steroid hormone axis in prostate cancer." @default.
- W75150274 created "2016-06-24" @default.
- W75150274 creator A5014512900 @default.
- W75150274 creator A5077644150 @default.
- W75150274 date "2012-01-01" @default.
- W75150274 modified "2023-09-25" @default.
- W75150274 title "Molecular Progression of Prostate Cancer: Androgens and Estrogens" @default.
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- W75150274 doi "https://doi.org/10.1007/978-1-60761-259-9_7" @default.
- W75150274 hasPublicationYear "2012" @default.