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• W752475946 abstract "Dynamic arterial spin labeling (ASL) MRI measures the perfusion bolus at multiple observation times and yields accurate estimates of cerebral blood flow in the presence of variations in arterial transit time. ASL has intrinsically low signal-to-noise ratio (SNR) and is sensitive to motion, so that extensive signal averaging is typically required, leading to long scan times for dynamic ASL. The goal of this study was to develop an accelerated dynamic ASL method with improved SNR and robustness to motion using a model-based image reconstruction that exploits the inherent sparsity of dynamic ASL data. The first component of this method is a single-shot 3D turbo spin echo spiral pulse sequence accelerated using a combination of parallel imaging and compressed sensing. This pulse sequence was then incorporated into a dynamic pseudo continuous ASL acquisition acquired at multiple observation times, and the resulting images were jointly reconstructed enforcing a model of potential perfusion time courses. Performance of the technique was verified using a numerical phantom and it was validated on normal volunteers on a 3-Tesla scanner. In simulation, a spatial sparsity constraint improved SNR and reduced estimation errors. Combined with a model-based sparsity constraint, the proposed method further improved SNR, reduced estimation error and suppressed motion artifacts. Experimentally, the proposed method resulted in significant improvements, with scan times as short as 20 s per time point. These results suggest that the model-based image reconstruction enables rapid dynamic ASL with improved accuracy and robustness." @default.
• W752475946 created "2016-06-24" @default.
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• W752475946 date "2015-11-01" @default.
• W752475946 modified "2023-10-16" @default.
• W752475946 title "Rapid 3D dynamic arterial spin labeling with a sparse model-based image reconstruction" @default.
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• W752475946 doi "https://doi.org/10.1016/j.neuroimage.2015.07.018" @default.
• W752475946 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4615585" @default.
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