Matches in SemOpenAlex for { <https://semopenalex.org/work/W75280112> ?p ?o ?g. }
- W75280112 endingPage "65" @default.
- W75280112 startingPage "1" @default.
- W75280112 abstract "This chapter presents an analytical review of epidemiology of multiple myeloma and related plasma cell disorders. A variety of etiologic factors may contribute to the development of multiple myeloma and related dyscrasias. The major risk indicator is age, with myeloma being especially common at older ages. Similarly, BMG also manifests a parallel old-age pattern, which may be etiologically related. In the postulated two hit mutation model, BMG may be one manifestation of the first hit, representing the controlled proliferation of a clone of plasma cell synthesizing the M-spike. The second hit occurs when another mutation leads to uncontrolled malignant proliferation. An age-dependent loss of regulatory cell function may be involved in the first hit by increasing the pool of terminally differentiated, immunoglobulin-secreting cells potentially available for malignant transformation. This old-age determinant may also help explain why an excess has not been found in some occupational and high-risk cohort studies which are limited in extent of long-term follow-up. Race is another important determinant. The higher rate and earlier age of onset of myeloma in Blacks suggests an inborn susceptibility, although environmental factors cannot be excluded. This may correlate with racial differences in baseline immunoglobulin levels 40 and with altered patterns of in vitro cellular response to mitogens in Blacks." @default.
- W75280112 created "2016-06-24" @default.
- W75280112 creator A5039473114 @default.
- W75280112 date "1980-01-01" @default.
- W75280112 modified "2023-10-16" @default.
- W75280112 title "Epidemiology of Multiple Myeloma and Related Plasma Cell Disorders: An Analytic Review" @default.
- W75280112 cites W114135256 @default.
- W75280112 cites W117268648 @default.
- W75280112 cites W1521384856 @default.
- W75280112 cites W1536836644 @default.
- W75280112 cites W1556977202 @default.
- W75280112 cites W1562082602 @default.
- W75280112 cites W1581907680 @default.
- W75280112 cites W1599996336 @default.
- W75280112 cites W168297186 @default.
- W75280112 cites W1810794458 @default.
- W75280112 cites W1844664773 @default.
- W75280112 cites W1898495819 @default.
- W75280112 cites W1901694970 @default.
- W75280112 cites W1918173167 @default.
- W75280112 cites W1925935711 @default.
- W75280112 cites W1939194707 @default.
- W75280112 cites W1964103022 @default.
- W75280112 cites W1964578957 @default.
- W75280112 cites W1965664122 @default.
- W75280112 cites W1966876266 @default.
- W75280112 cites W1968872997 @default.
- W75280112 cites W1969534089 @default.
- W75280112 cites W1969732814 @default.
- W75280112 cites W1971049322 @default.
- W75280112 cites W1971514621 @default.
- W75280112 cites W1974809812 @default.
- W75280112 cites W1975602236 @default.
- W75280112 cites W1977350715 @default.
- W75280112 cites W1978801685 @default.
- W75280112 cites W1979063983 @default.
- W75280112 cites W1980783943 @default.
- W75280112 cites W1981147553 @default.
- W75280112 cites W1983966910 @default.
- W75280112 cites W1984101374 @default.
- W75280112 cites W1984291940 @default.
- W75280112 cites W1986452513 @default.
- W75280112 cites W1987203070 @default.
- W75280112 cites W1988392742 @default.
- W75280112 cites W1992145764 @default.
- W75280112 cites W1992414419 @default.
- W75280112 cites W1993983443 @default.
- W75280112 cites W1994121671 @default.
- W75280112 cites W1997466495 @default.
- W75280112 cites W1998039073 @default.
- W75280112 cites W1998134941 @default.
- W75280112 cites W199964741 @default.
- W75280112 cites W2001077299 @default.
- W75280112 cites W2001214903 @default.
- W75280112 cites W2002055331 @default.
- W75280112 cites W2006269196 @default.
- W75280112 cites W2006801949 @default.
- W75280112 cites W2008152450 @default.
- W75280112 cites W200943382 @default.
- W75280112 cites W2010375666 @default.
- W75280112 cites W2010556041 @default.
- W75280112 cites W2012276249 @default.
- W75280112 cites W2013483011 @default.
- W75280112 cites W2014775262 @default.
- W75280112 cites W2014861565 @default.
- W75280112 cites W2014976039 @default.
- W75280112 cites W2015070529 @default.
- W75280112 cites W2016018630 @default.
- W75280112 cites W2018160235 @default.
- W75280112 cites W2019368554 @default.
- W75280112 cites W2019850957 @default.
- W75280112 cites W2020533667 @default.
- W75280112 cites W2020846591 @default.
- W75280112 cites W2020980093 @default.
- W75280112 cites W2021652014 @default.
- W75280112 cites W2022205955 @default.
- W75280112 cites W2024276493 @default.
- W75280112 cites W2024837047 @default.
- W75280112 cites W2026262092 @default.
- W75280112 cites W2029846050 @default.
- W75280112 cites W2029916712 @default.
- W75280112 cites W2031545354 @default.
- W75280112 cites W2033317452 @default.
- W75280112 cites W2033462216 @default.
- W75280112 cites W2036083619 @default.
- W75280112 cites W2036135280 @default.
- W75280112 cites W2038736421 @default.
- W75280112 cites W2041915525 @default.
- W75280112 cites W20429812 @default.
- W75280112 cites W2044162506 @default.
- W75280112 cites W2045940514 @default.
- W75280112 cites W2047536236 @default.
- W75280112 cites W2050037674 @default.
- W75280112 cites W2052346404 @default.
- W75280112 cites W2052346770 @default.
- W75280112 cites W2052488735 @default.
- W75280112 cites W2055338677 @default.
- W75280112 cites W2056010540 @default.