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- W75318034 abstract "1010 Objectives We describe the synthesis and in vivo application of gold nanoparticles coated with Gd-chelate (Au@GdL), for use as a potential bimodal MR/CT contrast agent and investigate the cell labeling efficiencies of Au@GdL. Methods The ligand (L), a conjugate of DTPA with cysteine, was prepared from the reaction of DTPA-bis(anhydride) with two equivalents of cysteine. The reaction of L with Gd2O3 in water under reflux led to the formation of GdL. The coating of AuNPs with GdL was accomplished by direct addition of GdL to a solution of citrate-coated AuNPs. T1 measurements were carried out using an inversion recovery method with a variable inversion time at 64 MHz. MR and CT images of mice were obtained pre- and post- Au@GdL injection by tail vein with a 1.5 Tesla MR unit (GE Healthcare) and INVEON (Simens Medical Solutions) CT scanner respectively. The glioma cells were labeled with Lipofectamine by incubating with Au@GdL. Results Characterization of these particles by HRTEM, XRD, TGA, and ICP reveals that the size of Au@GdL is 14 nm with the loading of GdL on AuNPs reaching up to 2.9×103 GdL per AuNP. Extremely high molecular R1 relaxivity (105mM-1s-1) as well as X-ray attenuation has been accomplished with Au@GdL. The R1 relaxivity per [Gd] is as high as 17.9 mM-1s-1. Quantitatively, an extra contrast enhancement of about 15% seems to be contributed by 2 wt% of gadolinium immobilized on AuNPs. In vivo MR and CT images show clear contrast enhancement with Au@GdL, and the strong enhancement is observed in the liver. The accumulation of Au@GdL in Kupffer cells can be further demonstrated by both histological and TEM images. HU value of 700 μg Au@GdL/ 3×105 glioma cell gave an equivalent X-ray absorption as 10 mM of Ultravist. Conclusions Au@GdL exhibits macrophage-specific property, as demonstrated by histological and TEM images as well as CT and MR. Au@GdL could be used as bimodal MR/CT contrast agent and potential imaging tools to track cells" @default.
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- W75318034 date "2010-05-01" @default.
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- W75318034 title "Design of gadolinium chelate coated gold nanoparticles for bimodality imaging and application for cell tracking" @default.
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