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• W753419744 abstract "XXIV ABSTRACT: Large animals were submitted to extensive small bowel resection and intestinal Large animals were submitted to extensive small bowel resection and intestinal transplant in the intention of establishing an experimental model for the Short bowel Syndrome and small bowel transplantation in swine. METHOD: Forty two Landrace Large White pigs were resected and divided in five groups: Group 1 (n = 6) 80% intestinal resection; Group 2 (n = 6), total intestinal resection; Group 3 (n = 6) total intestinal resection including ileocecal valve; Group 4 (n = 7) total intestinal resection and small bowel transplantation without immunosuppression and Group 5 (n = 5) total intestinal resection and small bowel transplantation with the use of immunosuppressant. Tacrolimus and mycophenolic acid was administered orally in the dose of 0,2 mg/kg/day and mycophenolic in the dose of 15 mg/kg/day. The level of tacrolimus was adjusted to 15-20 ng/ml. The follow-up of groups 1 and 2 was of 84 days, while in groups 3, 4 and 5 it was approximately 3 weeks. The postoperative evaluation included weekly control weight, clinical status and biochemical analysis (sodium, potassium, calcium, glycemia, urea, creatinine, triglycerides, total cholesterol, total proteins, albumin, and leukocyte count). Conventional endoscopies were performed weekly for graft biopsies to assess rejection. RESULTS: Group 1 gained weight suggesting small bowel adaptation, groups 2 and 3 lost weight, showing inadequate adaptation after resection. The pigs of group 4 and 5 died of acute cellular rejection and sepses, respectively. Only one animal in group 5 died by intussusception. Overall survival in groups 1, 2, 3, 4 and 5 at 30 days was 100 %, 100 %, 0 %, 0 % and 20 %, respectively. The medium survival in group 4 and 5 was 14 and 16 days, respectively. CONCLUSION: The evaluation of the groups allowed the following conclusions: 80% of small bowel resection did not allow the induction of short bowel syndrome; 100% small bowel resection supplied more adequate experimental model for short bowel studies; 100% small bowel resection with inclusion of ileocecal valve did not allow necessary survival for intestinal failure studies; and small bowel transplantation without immunosuppression lead to acute cellular rejection of the graft. The immunosuppression protocol used was adequate to prevent severe acute rejection, but inadequate to increase the overall survival. Moreover, rejection can be identified by using conventional endoscopy after small bowel transplantation." @default.
• W753419744 created "2016-06-24" @default.
• W753419744 creator A5065291622 @default.
• W753419744 date "2008-02-28" @default.
• W753419744 modified "2023-09-23" @default.
• W753419744 title "Síndrome do intestino curto e transplante intestinal: modelo experimental porcino" @default.
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