Matches in SemOpenAlex for { <https://semopenalex.org/work/W75343076> ?p ?o ?g. }
- W75343076 endingPage "76" @default.
- W75343076 startingPage "57" @default.
- W75343076 abstract "There is convincing evidence that the destruction of pancreatic B-cells leading to insulin-dependent diabetes mellitus (IDDM) is immunologically mediated1–3 and occurs in all mammals.4 Investigations of animal strains predominantly used in diabetes research, the NOD mouse and the BB rat, demonstrated that the acute onset of hyperglycemia is the final result of a chronic preclinical phase (prediabetes). Already during prediabetes and definitely at the onset of the disease, the number of pancreatic B-cells is reduced.5–11 In addition to the diminished number of B-cells, the pancreatic islets of prediabetic or newly diagnosed diabetic animals or patients are characterized by an invasion of immunocytes, so-called insulitis.5,6,9–14 The immunocytochemistry of invading mononuclear cells (MNC) reveals the presence of all major subsets, such as T-lymphocytes (CD4 and CD8 T-cells), B-lymphocytes, macrophages, and NK-cells.8,10–15 Electron microscopic investigations of inflafhed pancreatic islets demonstrated a close contact between immune cells and pancreatic B-cells. As a result of B-cell destruction, B-cell granules have been observed in the extracellular space.15–17 Although the molecular mechanism of B-cell killing is still not established, cytotoxic reactivities of CD4 T-cells,18 CD8 T-cells,19 NK cells,20 and macrophages21 against pancreatic B-cells have been demonstrated. In addition, it has been shown that the secretory products of immunocytes, the cytokines, may directly disrupt B-cells,22 or may induce surface proteins as MHC-antigens or adhesion molecules, which allow or facilitate cell-mediated killing of B-cells.23" @default.
- W75343076 created "2016-06-24" @default.
- W75343076 creator A5002607907 @default.
- W75343076 creator A5003947416 @default.
- W75343076 creator A5009264023 @default.
- W75343076 creator A5013758196 @default.
- W75343076 creator A5019259141 @default.
- W75343076 creator A5042830501 @default.
- W75343076 date "1996-01-01" @default.
- W75343076 modified "2023-09-30" @default.
- W75343076 title "Immunotherapy of insulin-dependent diabetes mellitus: Tolerance after short-term anti—;IL-2 receptor/cyclosporine therapy in BB/OK rats" @default.
- W75343076 cites W1560957286 @default.
- W75343076 cites W1590384635 @default.
- W75343076 cites W1966362059 @default.
- W75343076 cites W1979067233 @default.
- W75343076 cites W1984981950 @default.
- W75343076 cites W1986876944 @default.
- W75343076 cites W1988862052 @default.
- W75343076 cites W1993051112 @default.
- W75343076 cites W2005204898 @default.
- W75343076 cites W2011366727 @default.
- W75343076 cites W2013840807 @default.
- W75343076 cites W2016788870 @default.
- W75343076 cites W2018177578 @default.
- W75343076 cites W2019073639 @default.
- W75343076 cites W2023385413 @default.
- W75343076 cites W2024670462 @default.
- W75343076 cites W2026987834 @default.
- W75343076 cites W2039545446 @default.
- W75343076 cites W2042336731 @default.
- W75343076 cites W2042903180 @default.
- W75343076 cites W2046840068 @default.
- W75343076 cites W2050564398 @default.
- W75343076 cites W2052203156 @default.
- W75343076 cites W2057748755 @default.
- W75343076 cites W2058794781 @default.
- W75343076 cites W2060697160 @default.
- W75343076 cites W2060836240 @default.
- W75343076 cites W2061336900 @default.
- W75343076 cites W2063382470 @default.
- W75343076 cites W2064561114 @default.
- W75343076 cites W2064683523 @default.
- W75343076 cites W2067900021 @default.
- W75343076 cites W2068238618 @default.
- W75343076 cites W2069260751 @default.
- W75343076 cites W2072977048 @default.
- W75343076 cites W2079606535 @default.
- W75343076 cites W2082932794 @default.
- W75343076 cites W2088190808 @default.
- W75343076 cites W2088632285 @default.
- W75343076 cites W2102524411 @default.
- W75343076 cites W2106989652 @default.
- W75343076 cites W2107553126 @default.
- W75343076 cites W2117097757 @default.
- W75343076 cites W2118924566 @default.
- W75343076 cites W2120554371 @default.
- W75343076 cites W2134412880 @default.
- W75343076 cites W2140655516 @default.
- W75343076 cites W2159750923 @default.
- W75343076 cites W2160306941 @default.
- W75343076 cites W2325483557 @default.
- W75343076 cites W2332910275 @default.
- W75343076 cites W2405102278 @default.
- W75343076 cites W2418099410 @default.
- W75343076 cites W4246175961 @default.
- W75343076 doi "https://doi.org/10.1007/978-1-4612-4112-6_4" @default.
- W75343076 hasPublicationYear "1996" @default.
- W75343076 type Work @default.
- W75343076 sameAs 75343076 @default.
- W75343076 citedByCount "3" @default.
- W75343076 crossrefType "book-chapter" @default.
- W75343076 hasAuthorship W75343076A5002607907 @default.
- W75343076 hasAuthorship W75343076A5003947416 @default.
- W75343076 hasAuthorship W75343076A5009264023 @default.
- W75343076 hasAuthorship W75343076A5013758196 @default.
- W75343076 hasAuthorship W75343076A5019259141 @default.
- W75343076 hasAuthorship W75343076A5042830501 @default.
- W75343076 hasConcept C126322002 @default.
- W75343076 hasConcept C134018914 @default.
- W75343076 hasConcept C154317977 @default.
- W75343076 hasConcept C165220095 @default.
- W75343076 hasConcept C167672396 @default.
- W75343076 hasConcept C202751555 @default.
- W75343076 hasConcept C203014093 @default.
- W75343076 hasConcept C2777180221 @default.
- W75343076 hasConcept C2778013207 @default.
- W75343076 hasConcept C2779511750 @default.
- W75343076 hasConcept C2779668308 @default.
- W75343076 hasConcept C2779855799 @default.
- W75343076 hasConcept C55493867 @default.
- W75343076 hasConcept C555293320 @default.
- W75343076 hasConcept C55851684 @default.
- W75343076 hasConcept C71924100 @default.
- W75343076 hasConcept C86803240 @default.
- W75343076 hasConcept C8891405 @default.
- W75343076 hasConceptScore W75343076C126322002 @default.
- W75343076 hasConceptScore W75343076C134018914 @default.
- W75343076 hasConceptScore W75343076C154317977 @default.