FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W753497295> ?p ?o ?g. }

• W753497295 abstract "Hearing depends on faithful synaptic transmission at the inner hair cell (IHC) ribbon synapse, which is orchestrated by active zone proteins. RIM (Rab3 Interacting Molecules) is one of the active zone proteins and proposed to bind not only with multiple other presynaptic proteins, but also with synaptic vesicles and Ca2+ channels. In this study, the expression pattern and functions of RIMs in the IHCs were examined. Wild type IHCs express RIM2alpha and RIM3gamma at their active zone, whereas RIM1 is the major isoform in the CNS. Further electrophysiological analysis revealed that RIM2alpha regulates Ca2+-triggered exocytosis by controlling presynaptic L-type Ca2+ currents at the IHC ribbon synapse. This study clarifies that RIM2alpha underlies the normal hearing by controlling synaptic transmission at the IHCs ribbon synapse. In this thesis, the function of Clarin-1 protein, which is a causal protein for Usher syndrome type III, was also examined at the IHCs ribbon synapse. Although Clarin-1 was proposed to play a role in mechanoelectrical transduction, but the synaptic function remained unclear. The functional analysis demonstrates that Clarin-1 is not essential for synaptic transmission at the auditory first synapse." @default.
• W753497295 created "2016-06-24" @default.
• W753497295 creator A5061612236 @default.
• W753497295 date "2022-02-20" @default.
• W753497295 modified "2023-10-17" @default.
• W753497295 title "Expression and function of Rab3 interacting molecules and clarin-1 in inner hair cells" @default.
• W753497295 cites W1498955896 @default.
• W753497295 cites W1506027146 @default.
• W753497295 cites W1516563030 @default.
• W753497295 cites W153686783 @default.
• W753497295 cites W15453418 @default.
• W753497295 cites W1567128560 @default.
• W753497295 cites W1576023734 @default.
• W753497295 cites W1577134993 @default.
• W753497295 cites W1585555038 @default.
• W753497295 cites W1591639440 @default.
• W753497295 cites W1606945552 @default.
• W753497295 cites W1669625456 @default.
• W753497295 cites W1868187718 @default.
• W753497295 cites W1900274922 @default.
• W753497295 cites W1916825548 @default.
• W753497295 cites W1964189494 @default.
• W753497295 cites W1964650181 @default.
• W753497295 cites W1966743632 @default.
• W753497295 cites W1968669554 @default.
• W753497295 cites W1971757408 @default.
• W753497295 cites W1973841770 @default.
• W753497295 cites W1974813892 @default.
• W753497295 cites W1978641235 @default.
• W753497295 cites W1980057229 @default.
• W753497295 cites W1983968855 @default.
• W753497295 cites W1986733224 @default.
• W753497295 cites W1990107804 @default.
• W753497295 cites W1991145802 @default.
• W753497295 cites W1994729397 @default.
• W753497295 cites W1996702954 @default.
• W753497295 cites W2000501974 @default.
• W753497295 cites W2000554493 @default.
• W753497295 cites W2001228952 @default.
• W753497295 cites W2005019117 @default.
• W753497295 cites W2006623752 @default.
• W753497295 cites W2008014936 @default.
• W753497295 cites W2011889205 @default.
• W753497295 cites W2012649986 @default.
• W753497295 cites W2014809572 @default.
• W753497295 cites W2015373896 @default.
• W753497295 cites W2016799666 @default.
• W753497295 cites W2019832339 @default.
• W753497295 cites W2022792040 @default.
• W753497295 cites W2024031273 @default.
• W753497295 cites W2031573961 @default.
• W753497295 cites W2031814390 @default.
• W753497295 cites W2033328335 @default.
• W753497295 cites W2033670275 @default.
• W753497295 cites W2034142387 @default.
• W753497295 cites W2034223507 @default.
• W753497295 cites W2035657815 @default.
• W753497295 cites W2036459564 @default.
• W753497295 cites W2037924525 @default.
• W753497295 cites W2038502254 @default.
• W753497295 cites W2038717281 @default.
• W753497295 cites W2038774555 @default.
• W753497295 cites W2039707783 @default.
• W753497295 cites W2040128625 @default.
• W753497295 cites W2041733763 @default.
• W753497295 cites W2043559472 @default.
• W753497295 cites W2044500873 @default.
• W753497295 cites W2045878719 @default.
• W753497295 cites W2049458280 @default.
• W753497295 cites W2051524905 @default.
• W753497295 cites W2053068031 @default.
• W753497295 cites W2055275392 @default.
• W753497295 cites W2057934269 @default.
• W753497295 cites W2059524639 @default.
• W753497295 cites W2061569848 @default.
• W753497295 cites W2061677892 @default.
• W753497295 cites W2063509011 @default.
• W753497295 cites W2063582768 @default.
• W753497295 cites W2063609492 @default.
• W753497295 cites W2063731880 @default.
• W753497295 cites W2069665279 @default.
• W753497295 cites W2070074690 @default.
• W753497295 cites W2071469863 @default.
• W753497295 cites W2074378742 @default.
• W753497295 cites W2075773062 @default.
• W753497295 cites W2076227043 @default.
• W753497295 cites W2078577861 @default.
• W753497295 cites W2079297169 @default.
• W753497295 cites W2079971040 @default.
• W753497295 cites W2084528861 @default.
• W753497295 cites W2087896850 @default.
• W753497295 cites W2088495310 @default.
• W753497295 cites W2088854035 @default.
• W753497295 cites W2089019834 @default.
• W753497295 cites W2091543203 @default.
• W753497295 cites W2091869150 @default.
• W753497295 cites W2092209687 @default.
• W753497295 cites W2092670526 @default.
• W753497295 cites W2095470391 @default.
• W753497295 cites W2102991990 @default.

• next