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- W75372010 abstract "Objectives In the present study, we investigated the effects of the combination of noradrenaline into the LPBN and prazosin (α1-adrenoceptor antagonist) intraperitoneally (ip) on water and 0.3 M NaCl intake in rats treated with ip injection of the cholinergic agonist pilocarpine. Methods and results Male Holtzman rats with bilateral stainless steel guide-cannulas implanted into LPBN were used. Pilocarpine (1 mg/kg) injected ip induced water intake (2.9 ± 0.3 ml/180 min), without affecting 0.3 M NaCl intake (0.5 ± 0.3 ml/180 min). Bilateral injections of noradrenaline (80 nmol/0.2 μl) into the LPBN combined with ip prazosin (1 mg/kg) increased ip pilocarpine-induced water intake (6.3 ±1.7 ml/180 min) and 0.3 M NaCl intake (14.7 ± 3.5 ml/180 min). LPBN noradrenaline injections combined with ip saline did not affect 0.3 M NaCl (0.8 ± 2.4 ml/180 min) and decreased water intake (0.8 ± 0.3 ml/180 min) induced by ip pilocarpine. Prazosin ip did not modify 0.3 M NaCl (4.8 ± 3.6 ml/180 min) or water intake (0.5 ± 0.3 ml/180 min) in rats treated with pilocarpine ip combined saline into the LPBN. Conclusion The results suggest that strong cholinergic-induced sodium intake arises when the inhibitory mechanisms are deactivated with noradrenaline injected into the LPBN combined with the blockade of pressor responses with ip prazosin." @default.
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- W75372010 date "2012-04-01" @default.
- W75372010 modified "2023-10-01" @default.
- W75372010 title "PERIPHERAL PRAZOSIN COMBINED WITH NORADRENALINE INTO THE LATERAL PARABRACHIAL NUCLEUS FACILITATES CHOLINERGIC‐INDUCED SODIUM APPETITE" @default.
- W75372010 doi "https://doi.org/10.1096/fasebj.26.1_supplement.1103.18" @default.
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