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- W75380265 abstract "Background: There is strong evidence that short-term exposure to ozone (O 3 ) is associated with respiratory disease and death, but the effects of short-term exposure to ozone on ischemic heart and cerebrovascular disease have not been clearly established. Methods: Daily levels of urban O 3 pollution, the incidence of first-ever, recurrent, fatal and non-fatal ischemic cerebro-vascular events (ICVE) and myocardial infarction (MI) were compared using a bi-directional case-crossover design analysis. We analysed 1 574 ICVE and 913 MI that occurred in Dijon, France from 2001 to 2007. Sulphur dioxide (SO 2 ), nitrogen dioxide (NO 2 ), carbon monoxide (CO), particulate matter with an aerodiameter of ≤ 10μg/m3 (PM10) were used to create bi-pollutant models. Using the adjusted Odd Ratios (OR), the effects of O 3 exposure were calculated for every 10 μg/m3 increase in pollutants in multivariate logistic models adjusted for all possible confounders. Results: We found a statistically significant association between even low-levels of O 3 and recurrent ICVE with a 3-day lag (OR=1.115; 95%CI: 1.027–1.209). The association was marginally significant for recurrent MI with 1-day lag (OR=1.147; 95 % CI: 0.999–1.318). For incident events, we detected no significant association. In stratified analysis by vascular risk factors, we observed for ICVE an association with each vascular risk factor (OR=1.523; 95 % CI: 1.149–2.018) while for MI, an association with O 3 was found when hypercholesterolemia was present (OR=1.111; 95 %: 1.020–1.211). Moreover, we noted an increase in the strength of association with an increasing number of combined factors. Conclusions: From this population-based study, recurrent ICVE and MI could be triggered by short-term exposure to even low levels of O 3 , especially among subjects with severe vascular risk factors. As a result, preventive strategies could be designed for such subjects." @default.
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- W75380265 date "2010-11-23" @default.
- W75380265 modified "2023-09-28" @default.
- W75380265 title "Abstract 10399: Impact of Ozone Air Pollution on Ischemic Cerebral and Cardiac Events in Dijon, France." @default.
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