Matches in SemOpenAlex for { <https://semopenalex.org/work/W75399488> ?p ?o ?g. }
- W75399488 endingPage "68" @default.
- W75399488 startingPage "1" @default.
- W75399488 abstract "The physical properties of investigational molecules in drug discovery programmes have been the subjects of intense scrutiny, largely due to a propensity for the pursuit of examples where they are sub-optimal. This chapter introduces the noteworthy contributions that identified the shortcomings and then defines and discusses the key physical parameters (lipophilicity, pK a and solubility) and contemporary developments in their measurement and use. These physical characteristics impact the passage of a drug molecule from the administered dose to the site of action, profoundly influencing its pharmacokinetics and pharmacology. In particular, lipophilicity has a major influence on various parameters used to assess the developability of experimental molecules; the additional impact of aromaticity or flatness in structures and differentiation between the roles intrinsic (log P) and effective (log D) are also illustrated. In conclusion, the combined influences of good properties in efficient molecules are presented as powerful indicators of quality." @default.
- W75399488 created "2016-06-24" @default.
- W75399488 creator A5051609892 @default.
- W75399488 date "2014-01-01" @default.
- W75399488 modified "2023-10-16" @default.
- W75399488 title "Physical Properties in Drug Design" @default.
- W75399488 cites W107900956 @default.
- W75399488 cites W1515745795 @default.
- W75399488 cites W152943885 @default.
- W75399488 cites W1559462448 @default.
- W75399488 cites W1895993106 @default.
- W75399488 cites W1966915962 @default.
- W75399488 cites W1967234247 @default.
- W75399488 cites W1971297095 @default.
- W75399488 cites W1972721037 @default.
- W75399488 cites W1973734061 @default.
- W75399488 cites W1974290383 @default.
- W75399488 cites W1975099013 @default.
- W75399488 cites W1976065442 @default.
- W75399488 cites W1977121713 @default.
- W75399488 cites W1977363854 @default.
- W75399488 cites W1978336812 @default.
- W75399488 cites W1979189217 @default.
- W75399488 cites W1980095524 @default.
- W75399488 cites W1982462615 @default.
- W75399488 cites W1983591212 @default.
- W75399488 cites W1984627852 @default.
- W75399488 cites W1984673823 @default.
- W75399488 cites W1988724006 @default.
- W75399488 cites W1991590537 @default.
- W75399488 cites W1996973304 @default.
- W75399488 cites W1998700502 @default.
- W75399488 cites W1999197232 @default.
- W75399488 cites W2001051952 @default.
- W75399488 cites W2001054421 @default.
- W75399488 cites W2002285059 @default.
- W75399488 cites W2002719464 @default.
- W75399488 cites W2004753943 @default.
- W75399488 cites W2004947911 @default.
- W75399488 cites W2008525757 @default.
- W75399488 cites W2010182430 @default.
- W75399488 cites W2010425214 @default.
- W75399488 cites W2012626597 @default.
- W75399488 cites W2014203427 @default.
- W75399488 cites W2016347738 @default.
- W75399488 cites W2016575780 @default.
- W75399488 cites W2018285323 @default.
- W75399488 cites W2018288400 @default.
- W75399488 cites W2023577722 @default.
- W75399488 cites W2024149655 @default.
- W75399488 cites W2025718938 @default.
- W75399488 cites W2028105139 @default.
- W75399488 cites W2029040745 @default.
- W75399488 cites W2030624907 @default.
- W75399488 cites W2031503861 @default.
- W75399488 cites W2031576029 @default.
- W75399488 cites W2034549041 @default.
- W75399488 cites W2034613829 @default.
- W75399488 cites W2034977865 @default.
- W75399488 cites W2037964781 @default.
- W75399488 cites W2038094422 @default.
- W75399488 cites W2040066247 @default.
- W75399488 cites W2041767096 @default.
- W75399488 cites W2042695038 @default.
- W75399488 cites W2042721486 @default.
- W75399488 cites W2047161363 @default.
- W75399488 cites W2047710091 @default.
- W75399488 cites W2052002840 @default.
- W75399488 cites W2054790479 @default.
- W75399488 cites W2054884372 @default.
- W75399488 cites W2057302806 @default.
- W75399488 cites W2058298068 @default.
- W75399488 cites W2060039822 @default.
- W75399488 cites W2060757367 @default.
- W75399488 cites W2061481072 @default.
- W75399488 cites W2062458432 @default.
- W75399488 cites W2063442560 @default.
- W75399488 cites W2063544208 @default.
- W75399488 cites W2067232531 @default.
- W75399488 cites W2067468321 @default.
- W75399488 cites W2070305054 @default.
- W75399488 cites W2070789802 @default.
- W75399488 cites W2071158076 @default.
- W75399488 cites W2073762710 @default.
- W75399488 cites W2074274985 @default.
- W75399488 cites W2074502591 @default.
- W75399488 cites W2079038203 @default.
- W75399488 cites W2079443574 @default.
- W75399488 cites W2082291447 @default.
- W75399488 cites W2083354933 @default.
- W75399488 cites W2084836935 @default.
- W75399488 cites W2086106390 @default.
- W75399488 cites W2090907772 @default.
- W75399488 cites W2092156326 @default.
- W75399488 cites W2094802206 @default.
- W75399488 cites W2095179999 @default.
- W75399488 cites W2096095251 @default.
- W75399488 cites W2097559461 @default.