FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W754154988> ?p ?o ?g. }

• W754154988 abstract "Bax inhibitor 1 (BI-1) is a highly conserved protein originally identified as a suppressor of the proapoptotic protein Bax to inhibit cell death in animals and plants. The orthologs of BI-1 are widely distributed in filamentous fungi but their functions remain largely unknown. Herein, we report the identification and characterizations of MrBI-1, an ortholog of BI-1, in the entomopathogenic fungus Metarhizium robertsii. First, we found that MrBI-1 could partially rescue mammalian Bax-induced cell death in yeast. Deletion of MrBI-1 impaired fungal development, virulence and heat tolerance in M. robertsii. We also demonstrated that inactivation of MrBI-1 reduced fungal resistance to farnesol but not to hydrogen peroxide, suggesting that MrBI-1 contributes to antiapoptotic-like cell death via the endoplasmic reticulum stress-signaling pathway rather than the classical mitochondrium-dependent pathway. In particular, we found that unlike the observations in yeasts and plants, expression of mammalian Bax did not lead to a lethal effect in M. robertsii; however, it did aggravate the fungal apoptotic effect of farnesol. The results of this study advance our understanding of BI-1-like protein functions in filamentous fungi." @default.
• W754154988 created "2016-06-24" @default.
• W754154988 creator A5002114863 @default.
• W754154988 creator A5024214597 @default.
• W754154988 creator A5046162600 @default.
• W754154988 creator A5071518021 @default.
• W754154988 creator A5072775442 @default.
• W754154988 date "2015-05-29" @default.
• W754154988 modified "2023-09-24" @default.
• W754154988 title "The Bax inhibitor MrBI-1 regulates heat tolerance, apoptotic-like cell death and virulence in Metarhizium robertsii" @default.
• W754154988 cites W1479803402 @default.
• W754154988 cites W1901691741 @default.
• W754154988 cites W1965985446 @default.
• W754154988 cites W1967683520 @default.
• W754154988 cites W1969657382 @default.
• W754154988 cites W1970835750 @default.
• W754154988 cites W1975928103 @default.
• W754154988 cites W1985879199 @default.
• W754154988 cites W1986091383 @default.
• W754154988 cites W1988740497 @default.
• W754154988 cites W1997127808 @default.
• W754154988 cites W1997208169 @default.
• W754154988 cites W2003003290 @default.
• W754154988 cites W2004689990 @default.
• W754154988 cites W2009172278 @default.
• W754154988 cites W2010886618 @default.
• W754154988 cites W2016851054 @default.
• W754154988 cites W2021718796 @default.
• W754154988 cites W2023926016 @default.
• W754154988 cites W2025625871 @default.
• W754154988 cites W2031383352 @default.
• W754154988 cites W2033707520 @default.
• W754154988 cites W2047644930 @default.
• W754154988 cites W2060636452 @default.
• W754154988 cites W2064194904 @default.
• W754154988 cites W2083885985 @default.
• W754154988 cites W2086090484 @default.
• W754154988 cites W2086131233 @default.
• W754154988 cites W2093220551 @default.
• W754154988 cites W2094052752 @default.
• W754154988 cites W2097981960 @default.
• W754154988 cites W2098365491 @default.
• W754154988 cites W2103032991 @default.
• W754154988 cites W2112180603 @default.
• W754154988 cites W2113557226 @default.
• W754154988 cites W2115759619 @default.
• W754154988 cites W2122242230 @default.
• W754154988 cites W2127158412 @default.
• W754154988 cites W2131801978 @default.
• W754154988 cites W2133926500 @default.
• W754154988 cites W2136545373 @default.
• W754154988 cites W2137015675 @default.
• W754154988 cites W2139499348 @default.
• W754154988 cites W2146403286 @default.
• W754154988 cites W2150316927 @default.
• W754154988 cites W2152207030 @default.
• W754154988 cites W2153387414 @default.
• W754154988 cites W2158921674 @default.
• W754154988 cites W2162062509 @default.
• W754154988 cites W2171059622 @default.
• W754154988 doi "https://doi.org/10.1038/srep10625" @default.
• W754154988 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4448503" @default.
• W754154988 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26023866" @default.
• W754154988 hasPublicationYear "2015" @default.
• W754154988 type Work @default.
• W754154988 sameAs 754154988 @default.
• W754154988 citedByCount "14" @default.
• W754154988 countsByYear W7541549882016 @default.
• W754154988 countsByYear W7541549882017 @default.
• W754154988 countsByYear W7541549882018 @default.
• W754154988 countsByYear W7541549882019 @default.
• W754154988 countsByYear W7541549882020 @default.
• W754154988 countsByYear W7541549882023 @default.
• W754154988 crossrefType "journal-article" @default.
• W754154988 hasAuthorship W754154988A5002114863 @default.
• W754154988 hasAuthorship W754154988A5024214597 @default.
• W754154988 hasAuthorship W754154988A5046162600 @default.
• W754154988 hasAuthorship W754154988A5071518021 @default.
• W754154988 hasAuthorship W754154988A5072775442 @default.
• W754154988 hasBestOaLocation W7541549881 @default.
• W754154988 hasConcept C104317684 @default.
• W754154988 hasConcept C139447449 @default.
• W754154988 hasConcept C158617107 @default.
• W754154988 hasConcept C190283241 @default.
• W754154988 hasConcept C2777576037 @default.
• W754154988 hasConcept C2778700022 @default.
• W754154988 hasConcept C2779222958 @default.
• W754154988 hasConcept C2779247237 @default.
• W754154988 hasConcept C2779347548 @default.
• W754154988 hasConcept C2781292303 @default.
• W754154988 hasConcept C2910135453 @default.
• W754154988 hasConcept C31573885 @default.
• W754154988 hasConcept C43143990 @default.
• W754154988 hasConcept C54355233 @default.
• W754154988 hasConcept C55493867 @default.
• W754154988 hasConcept C59822182 @default.
• W754154988 hasConcept C60987743 @default.
• W754154988 hasConcept C62478195 @default.
• W754154988 hasConcept C86803240 @default.
• W754154988 hasConcept C89423630 @default.

• next