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- W75461928 abstract "2629 Objectives To deliver a reliable 4D-PET/CT imaging protocol and integrate with clinical PET/CT radiation treatment planning. Methods A trial population of 107 patients resulted in 116 individual studies during an 18 month period spanning 2008-2009. For each scan, there were approximately 3 hours of technologist time which led to additional robotic test time and protocol refining. There were more than 21 trial versions tested. In 2009 the first patients were treated using integrated 4D-PET/CT data. In 2010 several 4D-PET/CT protocols were standardized for use by Radiation Therapy. Over 100 patients (excluding trial population) have been scanned using 4D-PET/CT protocols as of Dec. 2011. Results 4D-PET/CT images greatly improve the delineation of tumor vs normal tissue for radiation treatment planning thus allowing radiation oncologists to better target tumor while limiting dose to normal tissue. Conclusions Standard imaging (2D or 3D) does not adequately represent moving tumors in lung, esophagus, liver, pancreas or other disease sites that may be strongly affected by respiration. Respiratory motion may cause a tumor to appear larger, to have greater depth, appear to encompass a vital blood supply or encroach upon a critical organ; small tumors/nodes may be lost in background signal. Consequently, motion may significantly alter SUV values. Assessment of tumor/organ motion may impact tumor staging and radiation treatment plan design. Technical aspects such as patient positioning, body habitus, and variable breathing patterns are challenges. Patient discomfort, non-respiratory patient movements and technical errors are obstacles. Practice is crucial. Mechanical errors may occur and troubleshooting knowledge of the various hardware components is essential" @default.
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- W75461928 date "2012-05-01" @default.
- W75461928 modified "2023-09-23" @default.
- W75461928 title "Clinical implementation of 4D-PET/CT: A technologist's perspective" @default.
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