Matches in SemOpenAlex for { <https://semopenalex.org/work/W75496150> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W75496150 endingPage "312" @default.
- W75496150 startingPage "308" @default.
- W75496150 abstract "Nonalcoholic steatohepatitis (NASH) was described by Ludwig mainly in obese, middle-aged women, often associated with diabetes mellitus and hyperlipidemia. In the recent years, NASH was found to be associated with male, nonobese, nondiabetic patients and with liver iron overload, which led to the hypothesis of iron playing a role in NASH pathogenesis. Increased ferritin with normal transferrin saturation is frequently found in fatty liver patients, but it reflects iron overload only in those patients in which it persists despite an appropriate diet. Insulin resistance hepatic iron overload (IR-HIO) is a new condition of hepatic iron overload, characterized by hyperferritinemia with normal or slightly increased transferrin saturation in the absence of hemochromatotic gene mutations. Although patients with IR-HIO have a high prevalence of insulin resistance-related metabolic disorders, the relationship of IR-HIO and NASH is unclear. Two characteristics allow differentiation of IR-HIO from genetic haemochromatosis: iron overload is heterogeneous from one hepatocyte to another in the periportal area, and sinusoidal iron is distributed throughout the lobule. In IR-HIO, fibrosis develops at a much lower hepatic iron burden than in genetic haemochromatosis, and sinusoidal iron, steatosis and inflammation could represent the histological mark of activity and progression of liver disease in IR-HIO." @default.
- W75496150 created "2016-06-24" @default.
- W75496150 creator A5036982451 @default.
- W75496150 creator A5039504054 @default.
- W75496150 creator A5050685536 @default.
- W75496150 date "2008-04-01" @default.
- W75496150 modified "2023-09-23" @default.
- W75496150 title "Involvement and role of iron in nonalcoholic steatohepatitis" @default.
- W75496150 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19294996" @default.
- W75496150 hasPublicationYear "2008" @default.
- W75496150 type Work @default.
- W75496150 sameAs 75496150 @default.
- W75496150 citedByCount "0" @default.
- W75496150 crossrefType "journal-article" @default.
- W75496150 hasAuthorship W75496150A5036982451 @default.
- W75496150 hasAuthorship W75496150A5039504054 @default.
- W75496150 hasAuthorship W75496150A5050685536 @default.
- W75496150 hasConcept C126322002 @default.
- W75496150 hasConcept C134018914 @default.
- W75496150 hasConcept C153852466 @default.
- W75496150 hasConcept C22814914 @default.
- W75496150 hasConcept C2775934546 @default.
- W75496150 hasConcept C2776175330 @default.
- W75496150 hasConcept C2776590208 @default.
- W75496150 hasConcept C2776954865 @default.
- W75496150 hasConcept C2777391703 @default.
- W75496150 hasConcept C2777766500 @default.
- W75496150 hasConcept C2778319317 @default.
- W75496150 hasConcept C2778772119 @default.
- W75496150 hasConcept C2779134260 @default.
- W75496150 hasConcept C2779478299 @default.
- W75496150 hasConcept C2780559512 @default.
- W75496150 hasConcept C2780942790 @default.
- W75496150 hasConcept C3019184707 @default.
- W75496150 hasConcept C555293320 @default.
- W75496150 hasConcept C71924100 @default.
- W75496150 hasConcept C86803240 @default.
- W75496150 hasConceptScore W75496150C126322002 @default.
- W75496150 hasConceptScore W75496150C134018914 @default.
- W75496150 hasConceptScore W75496150C153852466 @default.
- W75496150 hasConceptScore W75496150C22814914 @default.
- W75496150 hasConceptScore W75496150C2775934546 @default.
- W75496150 hasConceptScore W75496150C2776175330 @default.
- W75496150 hasConceptScore W75496150C2776590208 @default.
- W75496150 hasConceptScore W75496150C2776954865 @default.
- W75496150 hasConceptScore W75496150C2777391703 @default.
- W75496150 hasConceptScore W75496150C2777766500 @default.
- W75496150 hasConceptScore W75496150C2778319317 @default.
- W75496150 hasConceptScore W75496150C2778772119 @default.
- W75496150 hasConceptScore W75496150C2779134260 @default.
- W75496150 hasConceptScore W75496150C2779478299 @default.
- W75496150 hasConceptScore W75496150C2780559512 @default.
- W75496150 hasConceptScore W75496150C2780942790 @default.
- W75496150 hasConceptScore W75496150C3019184707 @default.
- W75496150 hasConceptScore W75496150C555293320 @default.
- W75496150 hasConceptScore W75496150C71924100 @default.
- W75496150 hasConceptScore W75496150C86803240 @default.
- W75496150 hasIssue "2" @default.
- W75496150 hasLocation W754961501 @default.
- W75496150 hasLocation W754961502 @default.
- W75496150 hasOpenAccess W75496150 @default.
- W75496150 hasPrimaryLocation W754961501 @default.
- W75496150 hasRelatedWork W100823909 @default.
- W75496150 hasRelatedWork W1992239176 @default.
- W75496150 hasRelatedWork W1994036484 @default.
- W75496150 hasRelatedWork W2048008333 @default.
- W75496150 hasRelatedWork W205958112 @default.
- W75496150 hasRelatedWork W2059764534 @default.
- W75496150 hasRelatedWork W2078009343 @default.
- W75496150 hasRelatedWork W2107537024 @default.
- W75496150 hasRelatedWork W2125378602 @default.
- W75496150 hasRelatedWork W2133202510 @default.
- W75496150 hasRelatedWork W2169595978 @default.
- W75496150 hasRelatedWork W2410794029 @default.
- W75496150 hasRelatedWork W2561821793 @default.
- W75496150 hasRelatedWork W2801275583 @default.
- W75496150 hasRelatedWork W2921859884 @default.
- W75496150 hasRelatedWork W2967913622 @default.
- W75496150 hasRelatedWork W3029895132 @default.
- W75496150 hasRelatedWork W3138664557 @default.
- W75496150 hasRelatedWork W1528912224 @default.
- W75496150 hasRelatedWork W1693946649 @default.
- W75496150 hasVolume "112" @default.
- W75496150 isParatext "false" @default.
- W75496150 isRetracted "false" @default.
- W75496150 magId "75496150" @default.
- W75496150 workType "article" @default.