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• W755163884 abstract "The effects of mechanical stress stimulation on bone fracture healing have been documented clinically over many years, and it has been known for some time that appropriate mechanical stimulation facilitates bone fracture healing. However, several studies have reported that certain types of stimulation can prevent bone union. Although many experiments have been conducted to determine the effects of mechanical stress stimulation on bone fracture healing, no conclusive findings have been made on the relationship between stimulation type and bone fracture healing. In this paper, the optimal mechanical stress stimulation for bone fracture healing was investigated. A total of 108 healthy rabbits were used to establish the V-shape tibial fracture models and determine the fracture healing effects at six(6) mechanical stress levels (s = 0, 1.13, 2.90, 3.97, 4.73, 6.02 kgf/ cm2) and four(4) fracture healing time points (t = 1, 3, 5, 8 weeks). The fracture healing was monitored by X-ray radiography. The radiographic findings were compared for each postoperative period. The experimental results were as follows: At 1 or 3 weeks after operations, no obvious healing effects could be found. At 5 weeks after operations, there existed a -shape relationship between healing score and mechanical stress of bone fracture. The optimal stress stimulation levels ranged from 2.90 to 4.73 kgf/cm2. These were the following fracture healing effects. When s= 2.90, 3.97, 4.73 kgf/cm2, the bone fracture line became indistinct or almost disappeared, and a great amount of callus had been able to joint two fracture ends. When s = 6.02 kgf/ cm2, bone fracture line was still clearly or partly visible, although a great amount of internal callus had been able to joint the related bone fracture ends. When s = 0, 1.13 kgf/cm2,bone fracture lines were very clearly visible and only little callus between two fracture ends was seen. At 8 weeks after operation, there also existed a -shape relationship between healing score and mechanical stress of bone fracture. It was similar to the healing effects at 8 weeks after operation. However, when s= 2.90, 3.97, 4.73 kgf/cm2, the bone fracture healing effect was better at 8 weeks than at 5 weeks after operation. In conclusion, the authors had described an open tibial fracture model of the midshaft tibia that showed distinctive patterns of bone fracture healing. Furthermore, it was implied from the stated x-ray observation results that the potential optimal mechanical stress stimulation and optimal fracture healing time were available. In detail, the mechanical stress level of 2.90-4.73 kgf/cm2 and fracture healing time of more than five(5) weeks comprised the optimal mechanical stress stimulation conditions to enhance tibial fracture healing." @default.
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• W755163884 date "2009-01-01" @default.
• W755163884 modified "2023-09-27" @default.
• W755163884 title "X-ray observation on tibial fracture healing due to mechanical stress stimulation" @default.
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