Matches in SemOpenAlex for { <https://semopenalex.org/work/W75534401> ?p ?o ?g. }
Showing items 1 to 58 of
58
with 100 items per page.
- W75534401 abstract "For digestion of starch, α-amylase first hydrolyzes the starch structure to α-limit dextrins (αLDx's). Complete hydrolysis to glucose then takes place through the combined action of mucosal maltase-glucoamylase (MGAM) and sucrase-isomaltase (SI), which have two subunits each (N- and C- terminal). In this study, we applied the concept of “toggling” through differential inhibition of subunits to examine control of glucogenesis from αLDx's with the aim of attaining slow glucose delivery to the body. Mammalian recombinant MGAM and SI subunits were individually reacted with αLDx's with varying concentrations of acarbose, a well known α-glucosidase inhibitor. Released glucose amounts were analyzed for hydrolysis activity. Notably, results showed selective inhibitory effect on C-terminal subunits by acarbose for starch digestion. Furthermore, Ki values of C-terminal subunits were lower than human α-amylases which can be applied that certain amount of acarbose had inhibitory effect on the hydrolysis of αLDx's by C-terminal subunits but not on α-amylase for moderating glucogenesis. This result supports the concept of controlling starch digestion rate for slow glucose release through the “toggling” of activities of the mucosal α-glucosidases by selective enzyme inhibition. Conceivably this approach could be used to treat Type II diabetes by extending postprandial blood glucose delivery to the body, and may apply as well to other metabolic syndrome-associated diseases and conditions. This research was supported from Whistler Center for Carbohydrate Research and USDA/AFRI." @default.
- W75534401 created "2016-06-24" @default.
- W75534401 creator A5012016543 @default.
- W75534401 creator A5022642132 @default.
- W75534401 creator A5042534841 @default.
- W75534401 creator A5046944655 @default.
- W75534401 creator A5089760163 @default.
- W75534401 date "2012-04-01" @default.
- W75534401 modified "2023-09-27" @default.
- W75534401 title "Modulation of starch digestion for slow glucose release through “toggling” of mucosal α‐glucosidases by acarbose" @default.
- W75534401 doi "https://doi.org/10.1096/fasebj.26.1_supplement.638.7" @default.
- W75534401 hasPublicationYear "2012" @default.
- W75534401 type Work @default.
- W75534401 sameAs 75534401 @default.
- W75534401 citedByCount "0" @default.
- W75534401 crossrefType "journal-article" @default.
- W75534401 hasAuthorship W75534401A5012016543 @default.
- W75534401 hasAuthorship W75534401A5022642132 @default.
- W75534401 hasAuthorship W75534401A5042534841 @default.
- W75534401 hasAuthorship W75534401A5046944655 @default.
- W75534401 hasAuthorship W75534401A5089760163 @default.
- W75534401 hasConcept C181199279 @default.
- W75534401 hasConcept C185592680 @default.
- W75534401 hasConcept C2776584326 @default.
- W75534401 hasConcept C2776617576 @default.
- W75534401 hasConcept C2781357212 @default.
- W75534401 hasConcept C31903555 @default.
- W75534401 hasConcept C43617362 @default.
- W75534401 hasConcept C529335014 @default.
- W75534401 hasConcept C55493867 @default.
- W75534401 hasConceptScore W75534401C181199279 @default.
- W75534401 hasConceptScore W75534401C185592680 @default.
- W75534401 hasConceptScore W75534401C2776584326 @default.
- W75534401 hasConceptScore W75534401C2776617576 @default.
- W75534401 hasConceptScore W75534401C2781357212 @default.
- W75534401 hasConceptScore W75534401C31903555 @default.
- W75534401 hasConceptScore W75534401C43617362 @default.
- W75534401 hasConceptScore W75534401C529335014 @default.
- W75534401 hasConceptScore W75534401C55493867 @default.
- W75534401 hasIssue "S1" @default.
- W75534401 hasLocation W755344011 @default.
- W75534401 hasOpenAccess W75534401 @default.
- W75534401 hasPrimaryLocation W755344011 @default.
- W75534401 hasRelatedWork W2007828960 @default.
- W75534401 hasRelatedWork W2030385139 @default.
- W75534401 hasRelatedWork W2085343245 @default.
- W75534401 hasRelatedWork W2384424196 @default.
- W75534401 hasRelatedWork W2927190448 @default.
- W75534401 hasRelatedWork W3012846034 @default.
- W75534401 hasRelatedWork W3046476059 @default.
- W75534401 hasRelatedWork W3175319226 @default.
- W75534401 hasRelatedWork W4200458315 @default.
- W75534401 hasRelatedWork W4309306655 @default.
- W75534401 hasVolume "26" @default.
- W75534401 isParatext "false" @default.
- W75534401 isRetracted "false" @default.
- W75534401 magId "75534401" @default.
- W75534401 workType "article" @default.