Matches in SemOpenAlex for { <https://semopenalex.org/work/W755597818> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W755597818 abstract "We examined both the chromosomal copy number changes and differential RNA expression profiles in Nasopharyngeal carcinoma (NPC). Gene expression profiles identified a large number of differentially regulated genes involved in diverse functional processes, while genetic analysis detected extensive genomic abnormalities including large and small, discrete regions of copy number change and loci that exhibit uniparental disomy (UPD). The relationship between chromosomal copy number and level of gene expression were analysed. This revealed that the direct copy number/expression link applies in about 60% of the instances of copy number loss/down-expression and less than 35% of instances of copy number gain/up-expression that were examined. Signalling pathway analysis revealed that numerous components involved in the TGF-β, Wnt/β-catenin and Hedgehog pathways were universally upregulated in NPC tumours, and gene expression pattern of the C666-1 cell line approximated to other NPC tumours, indicating that it is a good tumour model. A preliminary in vitro investigation of signalling pathways revealed that the C666-1 cell line is intact in the activin and Hh signalling pathways but not in the TGF-β pathway. However, the C666-1 cells appear to resist activin-mediated cell growth inhibition" @default.
- W755597818 created "2016-06-24" @default.
- W755597818 creator A5043258375 @default.
- W755597818 date "2010-12-01" @default.
- W755597818 modified "2023-09-24" @default.
- W755597818 title "Genetic and gene expression analysis of nasopharyngeal carcinoma (NPC)" @default.
- W755597818 cites W1983587444 @default.
- W755597818 cites W2057749060 @default.
- W755597818 cites W2092493179 @default.
- W755597818 cites W2152806824 @default.
- W755597818 hasPublicationYear "2010" @default.
- W755597818 type Work @default.
- W755597818 sameAs 755597818 @default.
- W755597818 citedByCount "0" @default.
- W755597818 crossrefType "dissertation" @default.
- W755597818 hasAuthorship W755597818A5043258375 @default.
- W755597818 hasConcept C104317684 @default.
- W755597818 hasConcept C120821319 @default.
- W755597818 hasConcept C126322002 @default.
- W755597818 hasConcept C137620995 @default.
- W755597818 hasConcept C141231307 @default.
- W755597818 hasConcept C150194340 @default.
- W755597818 hasConcept C153911025 @default.
- W755597818 hasConcept C18431079 @default.
- W755597818 hasConcept C2778539099 @default.
- W755597818 hasConcept C2778997737 @default.
- W755597818 hasConcept C502942594 @default.
- W755597818 hasConcept C509974204 @default.
- W755597818 hasConcept C54355233 @default.
- W755597818 hasConcept C71924100 @default.
- W755597818 hasConcept C86803240 @default.
- W755597818 hasConcept C88498014 @default.
- W755597818 hasConceptScore W755597818C104317684 @default.
- W755597818 hasConceptScore W755597818C120821319 @default.
- W755597818 hasConceptScore W755597818C126322002 @default.
- W755597818 hasConceptScore W755597818C137620995 @default.
- W755597818 hasConceptScore W755597818C141231307 @default.
- W755597818 hasConceptScore W755597818C150194340 @default.
- W755597818 hasConceptScore W755597818C153911025 @default.
- W755597818 hasConceptScore W755597818C18431079 @default.
- W755597818 hasConceptScore W755597818C2778539099 @default.
- W755597818 hasConceptScore W755597818C2778997737 @default.
- W755597818 hasConceptScore W755597818C502942594 @default.
- W755597818 hasConceptScore W755597818C509974204 @default.
- W755597818 hasConceptScore W755597818C54355233 @default.
- W755597818 hasConceptScore W755597818C71924100 @default.
- W755597818 hasConceptScore W755597818C86803240 @default.
- W755597818 hasConceptScore W755597818C88498014 @default.
- W755597818 hasLocation W7555978181 @default.
- W755597818 hasOpenAccess W755597818 @default.
- W755597818 hasPrimaryLocation W7555978181 @default.
- W755597818 hasRelatedWork W1997695524 @default.
- W755597818 hasRelatedWork W2003344363 @default.
- W755597818 hasRelatedWork W2020440343 @default.
- W755597818 hasRelatedWork W2047790795 @default.
- W755597818 hasRelatedWork W2056170952 @default.
- W755597818 hasRelatedWork W2088717951 @default.
- W755597818 hasRelatedWork W2099788018 @default.
- W755597818 hasRelatedWork W2128188406 @default.
- W755597818 hasRelatedWork W2151993159 @default.
- W755597818 hasRelatedWork W2152411486 @default.
- W755597818 hasRelatedWork W2158730662 @default.
- W755597818 hasRelatedWork W2162329623 @default.
- W755597818 hasRelatedWork W2162593630 @default.
- W755597818 hasRelatedWork W2385591410 @default.
- W755597818 hasRelatedWork W2399489477 @default.
- W755597818 hasRelatedWork W243705068 @default.
- W755597818 hasRelatedWork W2602825449 @default.
- W755597818 hasRelatedWork W2736605898 @default.
- W755597818 hasRelatedWork W2751236108 @default.
- W755597818 hasRelatedWork W2756839346 @default.
- W755597818 isParatext "false" @default.
- W755597818 isRetracted "false" @default.
- W755597818 magId "755597818" @default.
- W755597818 workType "dissertation" @default.