Matches in SemOpenAlex for { <https://semopenalex.org/work/W7557260> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W7557260 endingPage "36.14" @default.
- W7557260 startingPage "36.14" @default.
- W7557260 abstract "Abstract Mast cells play a critical role in the initiation and propagation of several inflammatory diseases and are well known for their function in the allergic response. Fullerenes are a class of novel carbon allotropes with a wide variety of applications in biotechnology and medicine. Here we use a fullerene-based chemistry platform to develop and test several different fullerene derivatives to evaluate on cellular viability, anti-IgE receptor-mediated degranulation, and cytokine release from human skin mast cells (MC). The biological response depended on the properties of the addition group; some fullerene structures were effective inhibitors of degranulation and also blocked cytokine release, while others were ineffective. None were toxic to the cells using concentrations up to 100 µg/ml. Further, we demonstrate that mitochondrial membrane potential (MMP) closely paralleled IgE-mediated SMC degranulatory responses and this response was greatly inhibited by fullerene pre-incubation. Additionally, the fullerene inhibition was due to the inhibition of FcεRI-mediated MAP kinase activation. These findings suggest the biological properties of fullerene derivatives depends on the derivatization of the carbon cage which can be manipulated to compounds which may control those diseases associated with MC activation." @default.
- W7557260 created "2016-06-24" @default.
- W7557260 creator A5002172845 @default.
- W7557260 creator A5004828232 @default.
- W7557260 creator A5022001155 @default.
- W7557260 creator A5030501347 @default.
- W7557260 creator A5047428796 @default.
- W7557260 creator A5052600404 @default.
- W7557260 creator A5084760419 @default.
- W7557260 creator A5091194849 @default.
- W7557260 date "2009-04-01" @default.
- W7557260 modified "2023-09-23" @default.
- W7557260 title "A Novel Nanomedicine Platform for Controlling Mast Cell Activation (36.14)" @default.
- W7557260 doi "https://doi.org/10.4049/jimmunol.182.supp.36.14" @default.
- W7557260 hasPublicationYear "2009" @default.
- W7557260 type Work @default.
- W7557260 sameAs 7557260 @default.
- W7557260 citedByCount "0" @default.
- W7557260 crossrefType "journal-article" @default.
- W7557260 hasAuthorship W7557260A5002172845 @default.
- W7557260 hasAuthorship W7557260A5004828232 @default.
- W7557260 hasAuthorship W7557260A5022001155 @default.
- W7557260 hasAuthorship W7557260A5030501347 @default.
- W7557260 hasAuthorship W7557260A5047428796 @default.
- W7557260 hasAuthorship W7557260A5052600404 @default.
- W7557260 hasAuthorship W7557260A5084760419 @default.
- W7557260 hasAuthorship W7557260A5091194849 @default.
- W7557260 hasConcept C12554922 @default.
- W7557260 hasConcept C141105273 @default.
- W7557260 hasConcept C159654299 @default.
- W7557260 hasConcept C162862793 @default.
- W7557260 hasConcept C170493617 @default.
- W7557260 hasConcept C178790620 @default.
- W7557260 hasConcept C185592680 @default.
- W7557260 hasConcept C202751555 @default.
- W7557260 hasConcept C203014093 @default.
- W7557260 hasConcept C2776953665 @default.
- W7557260 hasConcept C2778690821 @default.
- W7557260 hasConcept C2779726688 @default.
- W7557260 hasConcept C49802076 @default.
- W7557260 hasConcept C53227056 @default.
- W7557260 hasConcept C55493867 @default.
- W7557260 hasConcept C86803240 @default.
- W7557260 hasConcept C95444343 @default.
- W7557260 hasConceptScore W7557260C12554922 @default.
- W7557260 hasConceptScore W7557260C141105273 @default.
- W7557260 hasConceptScore W7557260C159654299 @default.
- W7557260 hasConceptScore W7557260C162862793 @default.
- W7557260 hasConceptScore W7557260C170493617 @default.
- W7557260 hasConceptScore W7557260C178790620 @default.
- W7557260 hasConceptScore W7557260C185592680 @default.
- W7557260 hasConceptScore W7557260C202751555 @default.
- W7557260 hasConceptScore W7557260C203014093 @default.
- W7557260 hasConceptScore W7557260C2776953665 @default.
- W7557260 hasConceptScore W7557260C2778690821 @default.
- W7557260 hasConceptScore W7557260C2779726688 @default.
- W7557260 hasConceptScore W7557260C49802076 @default.
- W7557260 hasConceptScore W7557260C53227056 @default.
- W7557260 hasConceptScore W7557260C55493867 @default.
- W7557260 hasConceptScore W7557260C86803240 @default.
- W7557260 hasConceptScore W7557260C95444343 @default.
- W7557260 hasIssue "1_Supplement" @default.
- W7557260 hasLocation W75572601 @default.
- W7557260 hasOpenAccess W7557260 @default.
- W7557260 hasPrimaryLocation W75572601 @default.
- W7557260 hasRelatedWork W1977460101 @default.
- W7557260 hasRelatedWork W2015409726 @default.
- W7557260 hasRelatedWork W2108873098 @default.
- W7557260 hasRelatedWork W2112577430 @default.
- W7557260 hasRelatedWork W2116493363 @default.
- W7557260 hasRelatedWork W2151538066 @default.
- W7557260 hasRelatedWork W2164396254 @default.
- W7557260 hasRelatedWork W2441743015 @default.
- W7557260 hasRelatedWork W3028993706 @default.
- W7557260 hasRelatedWork W3196011793 @default.
- W7557260 hasVolume "182" @default.
- W7557260 isParatext "false" @default.
- W7557260 isRetracted "false" @default.
- W7557260 magId "7557260" @default.
- W7557260 workType "article" @default.