FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W755769617> ?p ?o ?g. }

• W755769617 abstract "The catalytic mechanism of thymidylate synthase (TS) was investigated using X-ray crystallography: four structures that yield new information about the early stages of TS action are reported. TS catalyzes the production of thymidylate (TMP), one of the four nucleotide bases of DNA, from the substrate, deoxyuridylate and cofactor, methylenetetrahydrofolate (MTF). Knowledge about the TS mechanism is important for both the medical and basic sciences. TS is the sole de novo source of TMP and it is thus a target for anti-proliferative drugs aimed at addressing cancer and other diseases marked by rapidly dividing cells. To aid this effort, past research on TS has developed two models to explain how TS works. A detailed, sequential chemical mechanism explains the methylene and hydride transfers from one cofactor to the substrate. And, a two state, dynamical model explains the conformational change that TS undergoes during its catalytic cycle. Combining these two models will lead to a fuller understanding of protein structure, function, and dynamics interrelationships. Two of the new structures contain cofactor in a heretofore unseen state, bound in the active site with its imidazolidine ring intact. Finding that this is an allowed enzymeco factor state indicates that ring opening and formation of the highly reactive iminium cation may occur relatively late in the methylene transfer, after preparation of the" @default.
• W755769617 created "2016-06-24" @default.
• W755769617 creator A5035725377 @default.
• W755769617 date "2001-01-01" @default.
• W755769617 modified "2023-09-27" @default.
• W755769617 title "X-ray structures of novel intermediates in the thymidylate synthase models for chemical mechanism and conformational change" @default.
• W755769617 cites W1500523379 @default.
• W755769617 cites W1510646666 @default.
• W755769617 cites W1526908156 @default.
• W755769617 cites W1539158386 @default.
• W755769617 cites W1541556471 @default.
• W755769617 cites W1541992329 @default.
• W755769617 cites W1593839182 @default.
• W755769617 cites W1594948172 @default.
• W755769617 cites W1636203097 @default.
• W755769617 cites W1964521471 @default.
• W755769617 cites W1967146695 @default.
• W755769617 cites W1967391530 @default.
• W755769617 cites W1968344011 @default.
• W755769617 cites W1974452434 @default.
• W755769617 cites W1976795961 @default.
• W755769617 cites W1979420505 @default.
• W755769617 cites W1979844544 @default.
• W755769617 cites W1980335188 @default.
• W755769617 cites W1980467950 @default.
• W755769617 cites W1983111672 @default.
• W755769617 cites W1986191025 @default.
• W755769617 cites W1987367441 @default.
• W755769617 cites W1996927744 @default.
• W755769617 cites W2001575235 @default.
• W755769617 cites W2013083986 @default.
• W755769617 cites W2013264667 @default.
• W755769617 cites W2015701131 @default.
• W755769617 cites W2017002256 @default.
• W755769617 cites W2018444567 @default.
• W755769617 cites W2021110605 @default.
• W755769617 cites W2024480544 @default.
• W755769617 cites W2028218377 @default.
• W755769617 cites W2028231353 @default.
• W755769617 cites W2032130614 @default.
• W755769617 cites W2034346214 @default.
• W755769617 cites W2040794132 @default.
• W755769617 cites W2041360438 @default.
• W755769617 cites W2051056969 @default.
• W755769617 cites W2065303299 @default.
• W755769617 cites W2069430277 @default.
• W755769617 cites W2076538851 @default.
• W755769617 cites W2078163944 @default.
• W755769617 cites W2079717033 @default.
• W755769617 cites W2089727181 @default.
• W755769617 cites W2093527961 @default.
• W755769617 cites W2102085273 @default.
• W755769617 cites W2103794058 @default.
• W755769617 cites W2108900585 @default.
• W755769617 cites W2118849391 @default.
• W755769617 cites W2126461109 @default.
• W755769617 cites W2143707246 @default.
• W755769617 cites W2148259795 @default.
• W755769617 cites W2156026755 @default.
• W755769617 cites W2167175694 @default.
• W755769617 cites W2175749024 @default.
• W755769617 cites W2176123637 @default.
• W755769617 cites W2232183823 @default.
• W755769617 hasPublicationYear "2001" @default.
• W755769617 type Work @default.
• W755769617 sameAs 755769617 @default.
• W755769617 citedByCount "0" @default.
• W755769617 crossrefType "journal-article" @default.
• W755769617 hasAuthorship W755769617A5035725377 @default.
• W755769617 hasConcept C104317684 @default.
• W755769617 hasConcept C121608353 @default.
• W755769617 hasConcept C123321153 @default.
• W755769617 hasConcept C161790260 @default.
• W755769617 hasConcept C181199279 @default.
• W755769617 hasConcept C185592680 @default.
• W755769617 hasConcept C197957613 @default.
• W755769617 hasConcept C202751555 @default.
• W755769617 hasConcept C2776120743 @default.
• W755769617 hasConcept C2777339483 @default.
• W755769617 hasConcept C2778567177 @default.
• W755769617 hasConcept C2780456651 @default.
• W755769617 hasConcept C41183919 @default.
• W755769617 hasConcept C512185932 @default.
• W755769617 hasConcept C54355233 @default.
• W755769617 hasConcept C55493867 @default.
• W755769617 hasConcept C63338738 @default.
• W755769617 hasConcept C71240020 @default.
• W755769617 hasConcept C86803240 @default.
• W755769617 hasConceptScore W755769617C104317684 @default.
• W755769617 hasConceptScore W755769617C121608353 @default.
• W755769617 hasConceptScore W755769617C123321153 @default.
• W755769617 hasConceptScore W755769617C161790260 @default.
• W755769617 hasConceptScore W755769617C181199279 @default.
• W755769617 hasConceptScore W755769617C185592680 @default.
• W755769617 hasConceptScore W755769617C197957613 @default.
• W755769617 hasConceptScore W755769617C202751555 @default.
• W755769617 hasConceptScore W755769617C2776120743 @default.
• W755769617 hasConceptScore W755769617C2777339483 @default.
• W755769617 hasConceptScore W755769617C2778567177 @default.
• W755769617 hasConceptScore W755769617C2780456651 @default.

• next