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- W75580327 abstract "The central role that mitochondria play in cancer progression was highlighted by Otto Warburg in 1920s. He inferred that malignant cells synthesise ATP by metabolising glucose predominantly through glycolytic pathway rather than more efficient process of oxidative phosphorylation He proposed that such glycolytic ATP production is a universal property of malignant cells and that an impaired mitochondrial metabolism is a key event in development of carcinogenesis. More recent studies have revealed that in addition to their role in energy metabolism, mitochondria are also crucial regulator of apoptosis, a fundamental cellular function by which cells die in a well-controlled or programmed manner. Evasion of apoptosis is an important hallmark of cancer cell and a major cause of treatment failure. Therefore, targeting mitochondria is considered a promising strategy as it not only would affect the energy-dependent cell survival but also initiates the apoptotic pathway. This chapter would focus on the altered mitochondrial bioenergetics in tumour cells and their therapeutic implications." @default.
- W75580327 created "2016-06-24" @default.
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- W75580327 date "2014-12-05" @default.
- W75580327 modified "2023-09-24" @default.
- W75580327 title "Targeting Mitochondria: A Powerhouse Approach to Cancer Treatment" @default.
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- W75580327 doi "https://doi.org/10.1007/978-3-319-12253-3_16" @default.
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