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- W755919212 abstract "In vivo and in vitro animal studies have elucidated in some detail the biochemical pathways involved in the central and peripheral biosynthesis and degradation of phenylethylamine (PEA) (Figs. 1 and la; ref. 1–4 and work therein cited). Human studies of the metabolism of this amine are few and mostly deal with the measurement of PEA and of its main metabolite, phenylacetic acid in urine, plasma and cerebrospinal fluid (4–6). Several investigators have suggested that the observed changes in the peripheral levels of these substances in a number of neuropsychiatrie conditions may reflect variations in central PEA neuroactivity. On this rather weak evidence, it has been hypothesized that alterations in the brain PEA metabolism play a role in the pathophysiology of these disorders (1, 2,7). This communication presents the first evidence showing that in vitro human brain and liver preparations p-hydroxylate, N-methylate and N-acetylate PEA. It also reports on qualitative interspecie differences in the metabolism of PEA by these tissues. These preliminary results should encourage further research leading to the elucidation of the possible role of the “PEA metabolic pathway” in central mechanisms." @default.
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- W755919212 date "1985-01-01" @default.
- W755919212 modified "2023-09-27" @default.
- W755919212 title "Phenylethylamine Metabolism by Postmortem Human Brain and Liver Preparations" @default.
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- W755919212 doi "https://doi.org/10.1007/978-1-4612-5010-4_48" @default.
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