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- W756121775 abstract "We examined whether pretreatment with doxycycline (a matrix metalloproteinase MMP inhibitor) protects against acute pulmonary thromboembolism (APT)-induced right ventricular dysfunction and dilatation. APT (350 mg/kg of autologous blood clots) increased mean pulmonary artery pressure (MPAP) and pulmonary vascular resistance index (PVRI) by approximately 186% and 196% respectively. Ecocardiography showed that right ventricle (RV) diameter increased in animals with APT (from 10.7±0.8 to 18.3±1.6 mm, P<0.05), but not in embolized animals pretreated with doxycycline at 10 mg/kg i.v. (from 13.3±0.9 to 14.4±1.0 mm, P>0.05). Dobutamine stimulation induced minor improvements in RV function in embolized animals. However, doxycycline improved the RV contractile reserve. APT increased serum cardiac troponin I concentrations and RV gelatinolytic activity, and doxycycline prevented theses increases (P<0.05). These results suggest that MMPs are involved in APT-induced cardiomyocyte injury, RV dysfunction and dilatation, and degrade contractile proteins. Doxycycline improves the responses to dobutamine during APT. Funded by FAPESP, CNPq, and CAPES (Brazil)." @default.
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- W756121775 date "2012-04-01" @default.
- W756121775 modified "2023-10-01" @default.
- W756121775 title "Doxycycline protects against right ventricular dysfunction and dilatation caused by acute pulmonary thromboembolism" @default.
- W756121775 doi "https://doi.org/10.1096/fasebj.26.1_supplement.669.1" @default.
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