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• W75642076 abstract "Cancer is an important problem in public health worldwide. Gene therapy has the potential for improved treatment of cancer patients, particularly if used in combination with other, conventional therapies. To date, many strategies of gene therapy have been explored, including correction of mutant genes, immunstimulation, prodrug activation, interference of oncogene expression, and genetically modified oncolytic viruses. Although the preclinical results of gene therapy have shown promise for some cancers, cancer gene therapy is still at an early stage of clinical development and has not yet shown a significant therapeutic benefit for patients. The main obstacles to the introduction of gene therapy for patients are poor selectivity in vector targeting, inefficient gene transfer, and great difficulties in systemic application. Owing to the complex nature of targeted vector delivery to the tumor, strategies for gene therapy have focused their efforts on the development of local gene transfer to treat tumors locally for the benefit of the patient. This is not the answer for the treatment of a metastasizing systemic disease; however, it represents an important step toward the clinical applicability of cancer gene therapy. Furthermore, local control of tumor growth and progression could contribute to better control of the disease and improved quality of life for the patient." @default.
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• W75642076 date "2007-10-18" @default.
• W75642076 modified "2023-10-03" @default.
• W75642076 title "Local Gene Therapy for Cancer" @default.
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• W75642076 doi "https://doi.org/10.1007/978-1-59745-225-0_12" @default.
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