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- W75692318 endingPage "551" @default.
- W75692318 startingPage "517" @default.
- W75692318 abstract "This chapter discusses bacterial iron metabolism in infection and immunity. The injection of iron compounds can enhance the virulence of certain bacteria and, in some cases, can abolish passive immunity. The characteristic feature of the effect of iron is the stimulation of rapid bacterial multiplication in circumstances where it previously did not occur. Death is invariably caused by an overwhelming infection. The injection of iron compounds does not interfere with the action of complement or the neutralizing power of specific antitoxin. It also does not interfere with phagocytosis by leukocytes or the production of antibody. With some infections, iron compounds have little or no effect. Experiments in vitro have shown that the bacteriostatic or bactericidal effects of serum and milk can be abolished by saturating the iron-binding proteins—transferrin and lactoferrin—with iron. In the case of E. coli, the bacteriostatic effect appears to be because of the iron-binding protein and specific antibody acting together; with some organisms, such as P. septica, the presence of complement is also required. The iron-binding proteins do not bind heme compounds, and if hemoglobin is released from red cells in vivo, the iron in heme can be taken up by pathogenic bacteria if they have a binding site for the heme molecule. Thus, in some infections, such as those caused by E. coli or salmonellae, the presence of hemoglobin is responsible for rapid bacterial growth and a considerable enhancement of virulence." @default.
- W75692318 created "2016-06-24" @default.
- W75692318 creator A5004386721 @default.
- W75692318 creator A5039137151 @default.
- W75692318 creator A5076432754 @default.
- W75692318 date "1974-01-01" @default.
- W75692318 modified "2023-09-25" @default.
- W75692318 title "BACTERIAL IRON METABOLISM IN INFECTION AND IMMUNITY" @default.
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