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- W75702924 abstract "This chapter reviews the current data on patterns of bone loss with aging and gender that lead to osteoporosis in humans and the mechanisms by which these changes lead to osteoporosis, with particular emphasis on the potential role of immune cytokines in mediating these changes. It also focuses on the key role of estrogen deficiency in bone loss in both women and men, acting both by altering the regulatory cytokines and by other mechanisms. These effects are superimposed on age effects on bone cell function that are independent of both estrogen deficiency and alterations in the production and function of immune cytokines. The past decade has witnessed tremendous advances in our understanding of the pathogenesis of osteoporosis. Newer imaging approaches, including central and peripheral quantitative computed tomography (QCT) and high-resolution peripheral QCT (HRpQCT), have helped to more clearly define the overall pattern of bone mass acquisition and bone loss in both sexes. In addition, fundamental advances in bone biology, such as the discovery and characterization of the receptor-activator of nuclear factor kappa B ligand (RANKL)/RANK/osteoprotegerin (OPG) system, have provided new insights into the mediators of excessive bone resorption following sex steroid deficiency. Concurrent with this greater understanding of bone loss at the clinical and basic levels has been the increasing recognition of the close interactions between bone cells and immune cells, mediated by cytokines produced by both types of cells." @default.
- W75702924 created "2016-06-24" @default.
- W75702924 creator A5027073303 @default.
- W75702924 creator A5062958988 @default.
- W75702924 creator A5090023242 @default.
- W75702924 date "2011-01-01" @default.
- W75702924 modified "2023-09-23" @default.
- W75702924 title "The Role of the Immune System in the Development of Osteoporosis" @default.
- W75702924 cites W1537488315 @default.
- W75702924 cites W1543098232 @default.
- W75702924 cites W1561293749 @default.
- W75702924 cites W1593442063 @default.
- W75702924 cites W178823222 @default.
- W75702924 cites W1964555270 @default.
- W75702924 cites W1966125778 @default.
- W75702924 cites W1967937835 @default.
- W75702924 cites W1968506930 @default.
- W75702924 cites W1970787765 @default.
- W75702924 cites W1972880322 @default.
- W75702924 cites W1973076242 @default.
- W75702924 cites W1974660371 @default.
- W75702924 cites W1976909672 @default.
- W75702924 cites W1984340410 @default.
- W75702924 cites W1986580482 @default.
- W75702924 cites W1992053982 @default.
- W75702924 cites W1992438132 @default.
- W75702924 cites W1993231839 @default.
- W75702924 cites W1994756823 @default.
- W75702924 cites W1995579100 @default.
- W75702924 cites W1996028579 @default.
- W75702924 cites W1996395636 @default.
- W75702924 cites W1997323954 @default.
- W75702924 cites W1997722036 @default.
- W75702924 cites W2000442621 @default.
- W75702924 cites W2000851115 @default.
- W75702924 cites W2002306991 @default.
- W75702924 cites W2002924549 @default.
- W75702924 cites W2003733256 @default.
- W75702924 cites W2005204978 @default.
- W75702924 cites W2006145185 @default.
- W75702924 cites W2006184746 @default.
- W75702924 cites W2009566132 @default.
- W75702924 cites W2010524211 @default.
- W75702924 cites W2011011117 @default.
- W75702924 cites W2011398902 @default.
- W75702924 cites W2013724724 @default.
- W75702924 cites W2016222448 @default.
- W75702924 cites W2016439692 @default.
- W75702924 cites W2016674232 @default.
- W75702924 cites W2017945794 @default.
- W75702924 cites W2018316404 @default.
- W75702924 cites W2019172276 @default.
- W75702924 cites W2019539362 @default.
- W75702924 cites W2024932182 @default.
- W75702924 cites W2027396351 @default.
- W75702924 cites W2028580888 @default.
- W75702924 cites W2031041877 @default.
- W75702924 cites W2031293802 @default.
- W75702924 cites W2033402569 @default.
- W75702924 cites W2033754501 @default.
- W75702924 cites W2035416199 @default.
- W75702924 cites W2036051320 @default.
- W75702924 cites W2037050680 @default.
- W75702924 cites W2040884998 @default.
- W75702924 cites W2042827704 @default.
- W75702924 cites W2044054235 @default.
- W75702924 cites W2045731113 @default.
- W75702924 cites W2045765808 @default.
- W75702924 cites W2045789014 @default.
- W75702924 cites W2048299560 @default.
- W75702924 cites W2052602880 @default.
- W75702924 cites W2054249589 @default.
- W75702924 cites W2054689187 @default.
- W75702924 cites W2056598170 @default.
- W75702924 cites W2058362889 @default.
- W75702924 cites W2061470622 @default.
- W75702924 cites W2063780372 @default.
- W75702924 cites W2067754245 @default.
- W75702924 cites W2068014772 @default.
- W75702924 cites W2070395473 @default.
- W75702924 cites W2070656089 @default.
- W75702924 cites W2072050034 @default.
- W75702924 cites W2072231974 @default.
- W75702924 cites W2073649446 @default.
- W75702924 cites W2076067955 @default.
- W75702924 cites W2078019962 @default.
- W75702924 cites W2078406992 @default.
- W75702924 cites W2080756176 @default.
- W75702924 cites W2081028263 @default.
- W75702924 cites W2082529445 @default.
- W75702924 cites W2084535197 @default.
- W75702924 cites W2085086344 @default.
- W75702924 cites W2086753937 @default.
- W75702924 cites W2087726670 @default.
- W75702924 cites W2092099741 @default.
- W75702924 cites W2092505499 @default.
- W75702924 cites W2096234941 @default.
- W75702924 cites W2097430858 @default.