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- W757099092 abstract "Acquired immune deficiency syndrome (AIDS) and aging are associated with significant immune dysfunction and increased oxidative stress, resulting in increased susceptibility to opportunistic infections, cancers, autoimmune diseases, and death. Human immunodeficiency virus (HIV) infection and aging lower host defenses by modulating cvtokine production to alter T and B cell functions. The overall objective of this study is to determine effect of Murine AIDS (MAIDS), its cofactors and aging on opportunistic infection, and the potential of immunomodulation roles of dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) on ameliorating the immunological abnormality caused by retrovirus infection and aging. DHEA(S) was previously shown to have immune enhancing properties during (M.AIDS) and the aging. DHEA(S) significantly increased T-cell proliferation, restored secretion of Thl cytokines production, and normalized secretion of Th2 cytokine. Sur ival was significantly increased in the 29-month-old mice treated by DHEA. DHEAS plus antioxidants significantly normalized immune function, as well as maintained hepatic itamin E levels nearer control. In addition, DHEAS supplementation increased resistance to cr'ptosporidiosis in aged mice. Our study suggests that DHEA(S) alone and especially DHEAS plus antioxidant nutrients can prevent immune dysfunction in aging as well as aging, retrovirus infected mice. Chronic ethanol (EtOH) consumption causes immune dysfunction and furtlier exacerbates immune dysfunction and cytokine imbalance during MAJDS. DHEAS" @default.
- W757099092 created "2016-06-24" @default.
- W757099092 creator A5075832881 @default.
- W757099092 date "2000-01-01" @default.
- W757099092 modified "2023-09-22" @default.
- W757099092 title "Effect of murine retrovirus infection and aging on the immune defenses against to coxsackieviruses and Cryptosporidium parvum" @default.
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