Matches in SemOpenAlex for { <https://semopenalex.org/work/W75730122> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W75730122 endingPage "99.39" @default.
- W75730122 startingPage "99.39" @default.
- W75730122 abstract "Abstract IL-21 is a member of the IL-2 cytokine family that exerts potent biological effects on multiple hemopoietic cell types. It is produced by activated CD4 T cells, while its receptor, IL-21R, is found on cells including NK cells, dendritic, T cells and B cells. To investigate the role of IL-21 signaling in autoimmune disease, we addressed whether this cytokine contributes to the severe systemic lupus erythematosus (SLE)-like syndrome developed by BXSB-Yaa mice. We show that BXSB-Yaa CD4 T cells produce IL-21 but lack discriminative T follicular helper cell markers. We also show that BXSB-Yaa mice completely lacking the IL-21R or Igh6 are remarkably resistant to multiple aspects of the prototypic BXSB-Yaa autoimmune disease. Finally, we show that mixed bone marrow chimeric BXSB-Yaa mice lacking IL-21R specifically in the B-cell compartment are similarly resistant. These results suggest that IL-21 produced by a novel population of BXSB-Yaa CD4 T-cells acts through B-cells to evoke multiple features characteristic of severe SLE. The results indicate that IL-21 signaling through B-cells is an essential step in the pathogenesis of this SLE-like autoimmune disease and potentially others. Funded by an Arthritis Foundation grant to JB." @default.
- W75730122 created "2016-06-24" @default.
- W75730122 creator A5012950291 @default.
- W75730122 creator A5018199914 @default.
- W75730122 creator A5026308918 @default.
- W75730122 creator A5027575666 @default.
- W75730122 creator A5040423024 @default.
- W75730122 creator A5073095750 @default.
- W75730122 creator A5079348749 @default.
- W75730122 date "2009-04-01" @default.
- W75730122 modified "2023-09-23" @default.
- W75730122 title "IL-21 Receptor signaling by B-cells is essential for BXSB-Yaa pathogenesis (99.39)" @default.
- W75730122 doi "https://doi.org/10.4049/jimmunol.182.supp.99.39" @default.
- W75730122 hasPublicationYear "2009" @default.
- W75730122 type Work @default.
- W75730122 sameAs 75730122 @default.
- W75730122 citedByCount "0" @default.
- W75730122 crossrefType "journal-article" @default.
- W75730122 hasAuthorship W75730122A5012950291 @default.
- W75730122 hasAuthorship W75730122A5018199914 @default.
- W75730122 hasAuthorship W75730122A5026308918 @default.
- W75730122 hasAuthorship W75730122A5027575666 @default.
- W75730122 hasAuthorship W75730122A5040423024 @default.
- W75730122 hasAuthorship W75730122A5073095750 @default.
- W75730122 hasAuthorship W75730122A5079348749 @default.
- W75730122 hasConcept C120642132 @default.
- W75730122 hasConcept C129374314 @default.
- W75730122 hasConcept C159654299 @default.
- W75730122 hasConcept C203014093 @default.
- W75730122 hasConcept C2776090121 @default.
- W75730122 hasConcept C2778690821 @default.
- W75730122 hasConcept C2779075594 @default.
- W75730122 hasConcept C86803240 @default.
- W75730122 hasConcept C8891405 @default.
- W75730122 hasConceptScore W75730122C120642132 @default.
- W75730122 hasConceptScore W75730122C129374314 @default.
- W75730122 hasConceptScore W75730122C159654299 @default.
- W75730122 hasConceptScore W75730122C203014093 @default.
- W75730122 hasConceptScore W75730122C2776090121 @default.
- W75730122 hasConceptScore W75730122C2778690821 @default.
- W75730122 hasConceptScore W75730122C2779075594 @default.
- W75730122 hasConceptScore W75730122C86803240 @default.
- W75730122 hasConceptScore W75730122C8891405 @default.
- W75730122 hasIssue "1_Supplement" @default.
- W75730122 hasLocation W757301221 @default.
- W75730122 hasOpenAccess W75730122 @default.
- W75730122 hasPrimaryLocation W757301221 @default.
- W75730122 hasRelatedWork W1788119937 @default.
- W75730122 hasRelatedWork W2006474879 @default.
- W75730122 hasRelatedWork W2011038290 @default.
- W75730122 hasRelatedWork W2038721818 @default.
- W75730122 hasRelatedWork W2044459036 @default.
- W75730122 hasRelatedWork W2056065139 @default.
- W75730122 hasRelatedWork W2155353257 @default.
- W75730122 hasRelatedWork W2375289158 @default.
- W75730122 hasRelatedWork W2998343095 @default.
- W75730122 hasRelatedWork W89674234 @default.
- W75730122 hasVolume "182" @default.
- W75730122 isParatext "false" @default.
- W75730122 isRetracted "false" @default.
- W75730122 magId "75730122" @default.
- W75730122 workType "article" @default.