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- W75806907 abstract "From annual meeting of the Deutsche Gesellschaft fuer Biophysik; Juelich, Germany (27 Sep 1973). A model investigation was made of the aldehyde dehydrogenase in yeast in order to determine whether the radiation-induced loss of K/sup +/ ions will have different effects on the cell metabolism, depending on the K/sup +/ activation of a reaction. This enzyme is activated by K/sup +/ ions and is inhibited by an excess amount of substrate, with the K/sup +/ activation decreasing with increasing substrate inhibition. This system was chosen as it allows the K/sup +/ content and K/sup +/ activation to be varied within a wide range and therefore lends itself to a more differentiated study of the effects of radiation-induced losses of K/sup +/ ions. Different substrate concentrations and extracellular K/sup +/ concentrations were used for the experiment and it was found that irradiation with 200 kR always results in a loss of K/sup +/ ions of equal order of magnitude, in spite of the variation of parameters. The same amount of last K/sup +/ ions, however, caused various changes in the respiration rate, depending on the substrate concentration. The results show that equal K/ sup +/ losses will have a different effectmore » that depends on the ability of the system under investigation to be activated by K/sup +/ ions. Radiation-induced losses of K/sup +/ ions will have only a minor effect on O/sub 2/ consumption if the system's activation by K/sup +/ ions is weak, whereas in the opposite case, already small losses of K/sup +/ ions will induce considerable changes in O/sub 2/ consumption. (GE)« less" @default.
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- W75806907 date "1973-01-01" @default.
- W75806907 modified "2023-09-27" @default.
- W75806907 title "Radiation effects on metabolic systems activated by K$sup +$" @default.
- W75806907 hasPublicationYear "1973" @default.
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