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- W75855188 abstract "Tubulitis in the kidney is defined as the presence of inflammatory cells in the tubular wall (OOi et al. 1975). It is the hallmark of tubulointerstitial nephritis (OLsen etal. 1986) and one of the important lesions in acute renal allograft rejection (SOlez et al. 1993). However, it may occur in other renal diseases as well, e.g., glomerulonephritis and acute tubular necrosis (OLsen etal. 1981), systemic vasculitis affecting the kidney (AKisusa etal. 1990), chronic renal ischemia (TRuong etal. 1992). Knowledge of the clinical implications, pathogenesis, and consequences of tubulitis is limited due to the complex structural–functional relationships between the tubular epithelium, the peritubular interstitium, and the capillaries and the complicated segmental structure of the tubules. It seems likely that tubulitis is in most cases a result of a T-cell-mediated reaction. Studies of human renal allograft rejection (Sect. 7.1) and autoimmune nephritis in mice (KElley et al. 1993) led to the hypothesis that renal tubular epithelial cells may participate in the development of tubulitis, since they can be induced to express major histocompatibility complex (MHC) molecules and cell adhesion molecules, and present antigen to T cells (HAgerty and ALlen 1992)." @default.
- W75855188 created "2016-06-24" @default.
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- W75855188 date "1995-01-01" @default.
- W75855188 modified "2023-09-25" @default.
- W75855188 title "Tubulitis in Renal Disease" @default.
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- W75855188 doi "https://doi.org/10.1007/978-3-642-79517-6_5" @default.
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