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- W75889723 abstract "It has been shown that the nephrotoxicity of cephaloridine is enhanced by pre-treatment with the inhibitors of renal cation transport, cyanine or mepiperphenidol. This report describes experiments directed towards determining the mechanism of this effect. The nephrotoxicity of cephaloridine has been shown to be closely dependent upon renal cortical concentrations. Cyanine does not alter the uptake of cephaloridine either invivo or invitro. However, renal cortical concentrations cephaloridine at later time points after the administration of the antibiotic are significantly higher in cyanine pre-treated animals. The efflux of cephaloridine from preloaded renal cortical slices is significantly slowed by the presence of cyanine or mepiperphenidol in the efflux media. It was concluded that cephaloridine depends on a relatively inactive but necessary cationic transport step for exit from proximal tubular cells and an inhibition of this transport results in increased cortical concentrations, particularly at later time points after the dose which would explain the enhanced nephrotoxicity observed after pretreatment with cation transport inhibitors." @default.
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- W75889723 date "1980-12-01" @default.
- W75889723 modified "2023-10-12" @default.
- W75889723 title "The effect of renal cation transport inhibitors on the and accumulation and efflux of cephaloridine" @default.
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- W75889723 doi "https://doi.org/10.1016/0024-3205(80)90539-1" @default.
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