FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W75896693> ?p ?o ?g. }

• W75896693 endingPage "7" @default.
• W75896693 startingPage "303" @default.
• W75896693 abstract "Capecitabine is the reference treatment for anthracycline- and/or taxane-pretreated metastatic breast cancer (MBC). This study examined its efficacy, tolerability and impact on the quality of life of elderly patients with MBC.Between January 2002 and December 2009, 75 consecutive elderly patients with MBC received first-line chemotherapy with capecitabine 1000 mg/m2 twice daily for 14 days every 3 weeks. Endpoints were efficacy, tolerability and clinical-benefit response measured every 3 cycles.Median age was 76 years (range 65-88); median ECOG performance status was 1 (range 0-2); 51 patients (68%) had received adjuvant chemotherapy and all patients had received hormonal therapy. Median exposure was 6 cycles. After 3 cycles, 11 patients (14.7%) had a partial response, one patient experienced a complete response, and 49 patients (65.3%) had stable disease, amounting to a disease control rate of 81.3%. Stable disease was maintained in 45 patients (60%) after 6 cycles, in 21 patients (28%) after 9 cycles, and in 13 patients (17.3%) after 12 cycles. A clinical-benefit response was experienced by 42 patients (56%), indicating a positive impact on quality of life. Treatment was well tolerated, the most common grade 3 events being diarrhea (12%) hand-foot syndrome (8%), and mucositis (8%). Adverse events were managed with dose adjustments and supportive therapy when required.Our results indicate that capecitabine is active and well tolerated in elderly patients with MBC. This dosing regimen warrants further study in the first-line setting for patients with less aggressive MBC who are not candidates for combination therapy." @default.
• W75896693 created "2016-06-24" @default.
• W75896693 creator A5002408463 @default.
• W75896693 creator A5013144248 @default.
• W75896693 creator A5017447682 @default.
• W75896693 creator A5022389138 @default.
• W75896693 creator A5024344441 @default.
• W75896693 creator A5028024983 @default.
• W75896693 creator A5039572266 @default.
• W75896693 creator A5044131985 @default.
• W75896693 creator A5065454514 @default.
• W75896693 creator A5073021827 @default.
• W75896693 creator A5076546888 @default.
• W75896693 creator A5084550009 @default.
• W75896693 creator A5089955989 @default.
• W75896693 date "2012-07-25" @default.
• W75896693 modified "2023-09-24" @default.
• W75896693 title "Capecitabine in elderly patients with metastatic breast cancer." @default.
• W75896693 cites W1939003096 @default.
• W75896693 cites W1966574632 @default.
• W75896693 cites W1966888775 @default.
• W75896693 cites W1978054127 @default.
• W75896693 cites W2001433631 @default.
• W75896693 cites W2039310969 @default.
• W75896693 cites W2040287930 @default.
• W75896693 cites W2044970916 @default.
• W75896693 cites W2055976662 @default.
• W75896693 cites W2066582161 @default.
• W75896693 cites W2096924600 @default.
• W75896693 cites W2096995059 @default.
• W75896693 cites W2099199992 @default.
• W75896693 cites W2099658604 @default.
• W75896693 cites W2114159573 @default.
• W75896693 cites W2115428190 @default.
• W75896693 cites W2123732467 @default.
• W75896693 cites W2139248078 @default.
• W75896693 cites W2143399650 @default.
• W75896693 cites W2154109174 @default.
• W75896693 cites W2160362526 @default.
• W75896693 cites W2165181244 @default.
• W75896693 cites W2165782026 @default.
• W75896693 cites W2323433130 @default.
• W75896693 doi "https://doi.org/10.1700/1125.12396" @default.
• W75896693 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22825504" @default.
• W75896693 hasPublicationYear "2012" @default.
• W75896693 type Work @default.
• W75896693 sameAs 75896693 @default.
• W75896693 citedByCount "2" @default.
• W75896693 countsByYear W758966932015 @default.
• W75896693 crossrefType "journal-article" @default.
• W75896693 hasAuthorship W75896693A5002408463 @default.
• W75896693 hasAuthorship W75896693A5013144248 @default.
• W75896693 hasAuthorship W75896693A5017447682 @default.
• W75896693 hasAuthorship W75896693A5022389138 @default.
• W75896693 hasAuthorship W75896693A5024344441 @default.
• W75896693 hasAuthorship W75896693A5028024983 @default.
• W75896693 hasAuthorship W75896693A5039572266 @default.
• W75896693 hasAuthorship W75896693A5044131985 @default.
• W75896693 hasAuthorship W75896693A5065454514 @default.
• W75896693 hasAuthorship W75896693A5073021827 @default.
• W75896693 hasAuthorship W75896693A5076546888 @default.
• W75896693 hasAuthorship W75896693A5084550009 @default.
• W75896693 hasAuthorship W75896693A5089955989 @default.
• W75896693 hasConcept C121608353 @default.
• W75896693 hasConcept C126322002 @default.
• W75896693 hasConcept C143998085 @default.
• W75896693 hasConcept C159110408 @default.
• W75896693 hasConcept C197934379 @default.
• W75896693 hasConcept C2775930923 @default.
• W75896693 hasConcept C2776694085 @default.
• W75896693 hasConcept C2776802502 @default.
• W75896693 hasConcept C2777511904 @default.
• W75896693 hasConcept C2777909004 @default.
• W75896693 hasConcept C2778375690 @default.
• W75896693 hasConcept C2778496288 @default.
• W75896693 hasConcept C2778822529 @default.
• W75896693 hasConcept C2779951463 @default.
• W75896693 hasConcept C2781413609 @default.
• W75896693 hasConcept C526805850 @default.
• W75896693 hasConcept C530470458 @default.
• W75896693 hasConcept C71924100 @default.
• W75896693 hasConceptScore W75896693C121608353 @default.
• W75896693 hasConceptScore W75896693C126322002 @default.
• W75896693 hasConceptScore W75896693C143998085 @default.
• W75896693 hasConceptScore W75896693C159110408 @default.
• W75896693 hasConceptScore W75896693C197934379 @default.
• W75896693 hasConceptScore W75896693C2775930923 @default.
• W75896693 hasConceptScore W75896693C2776694085 @default.
• W75896693 hasConceptScore W75896693C2776802502 @default.
• W75896693 hasConceptScore W75896693C2777511904 @default.
• W75896693 hasConceptScore W75896693C2777909004 @default.
• W75896693 hasConceptScore W75896693C2778375690 @default.
• W75896693 hasConceptScore W75896693C2778496288 @default.
• W75896693 hasConceptScore W75896693C2778822529 @default.
• W75896693 hasConceptScore W75896693C2779951463 @default.
• W75896693 hasConceptScore W75896693C2781413609 @default.
• W75896693 hasConceptScore W75896693C526805850 @default.
• W75896693 hasConceptScore W75896693C530470458 @default.

• next