Matches in SemOpenAlex for { <https://semopenalex.org/work/W759178093> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W759178093 abstract "Several epidemiological and clinical studies have demonstrated the inverse correlation between the plasma concentration of high density lipoprotein (HDL) cholesterol and the risk of myocardial infarction (reviewed in ref. 1). The ability of HDL to protect the vessel wall from atherosclerosis has usually been explained by the reverse cholesterol transport model (reviewed in ref. 2) in which HDL mediates the flux of excess cholesterol from peripheral cells to the liver. HDL-cholesterol levels are determined by environmental and genetic factors. The influence of genes on the variation of HDL-cholesterol levels has been estimated to account for up to 50%, but only rare defects in the genes of apolipoprotein (apo)A-I and lecithin:cholesterol acyltransferase (LCAT) could be made responsible for familially low HDL-cholesterol levels3. Despite the virtual absence of HDL, several homozygotes for apoA-I deficiency, LCAT deficiency, and fish-eye disease, but also patients with Tangier disease or unclassified forms of HDL deficiency did not present with premature atherosclerosis3–6. Family histories of these patients did not indicate any increased prevalence of coronary heart disease (CHD) events, although heterozygotes for various defects in the genes of apoA-I and LCAT, as well as obligate heterozygotes for Tangier disease, usually have HDL-cholesterol levels below the 10th percentile of sex- and age- matched controls3,5,6. These clinical observations have questioned a direct anti-atherogenic role of HDL. HDL, however, include structurally and functionally heterogeneous lipoproteins which can be differentiated on the basis of density, size, charge and apolipoprotein composition7. During recent years, experiments of our and other investigators’ laboratories have yielded a large body of evidence showing that minor subtractions of HDL which escape the quantification of HDL-cholesterol are important contributors to reverse cholesterol transport." @default.
- W759178093 created "2016-06-24" @default.
- W759178093 creator A5021746678 @default.
- W759178093 creator A5024330806 @default.
- W759178093 creator A5027046285 @default.
- W759178093 date "1995-01-01" @default.
- W759178093 modified "2023-09-27" @default.
- W759178093 title "Role of high density lipoprotein subclasses in reverse cholesterol transport" @default.
- W759178093 cites W1982396383 @default.
- W759178093 cites W1983457976 @default.
- W759178093 cites W1991780131 @default.
- W759178093 cites W1996603800 @default.
- W759178093 cites W2006544201 @default.
- W759178093 cites W2034601582 @default.
- W759178093 cites W2048978769 @default.
- W759178093 cites W2063246145 @default.
- W759178093 cites W2079793886 @default.
- W759178093 cites W2080488210 @default.
- W759178093 cites W2083392018 @default.
- W759178093 cites W2091162454 @default.
- W759178093 cites W2101110382 @default.
- W759178093 cites W2117064337 @default.
- W759178093 cites W2339616051 @default.
- W759178093 doi "https://doi.org/10.1007/978-94-011-6585-3_2" @default.
- W759178093 hasPublicationYear "1995" @default.
- W759178093 type Work @default.
- W759178093 sameAs 759178093 @default.
- W759178093 citedByCount "1" @default.
- W759178093 crossrefType "book-chapter" @default.
- W759178093 hasAuthorship W759178093A5021746678 @default.
- W759178093 hasAuthorship W759178093A5024330806 @default.
- W759178093 hasAuthorship W759178093A5027046285 @default.
- W759178093 hasConcept C104317684 @default.
- W759178093 hasConcept C110459506 @default.
- W759178093 hasConcept C126322002 @default.
- W759178093 hasConcept C134018914 @default.
- W759178093 hasConcept C149011108 @default.
- W759178093 hasConcept C153471976 @default.
- W759178093 hasConcept C180754005 @default.
- W759178093 hasConcept C2777704780 @default.
- W759178093 hasConcept C2778163477 @default.
- W759178093 hasConcept C2779982054 @default.
- W759178093 hasConcept C2780072125 @default.
- W759178093 hasConcept C2780541478 @default.
- W759178093 hasConcept C37002583 @default.
- W759178093 hasConcept C54355233 @default.
- W759178093 hasConcept C62746215 @default.
- W759178093 hasConcept C71924100 @default.
- W759178093 hasConcept C86803240 @default.
- W759178093 hasConceptScore W759178093C104317684 @default.
- W759178093 hasConceptScore W759178093C110459506 @default.
- W759178093 hasConceptScore W759178093C126322002 @default.
- W759178093 hasConceptScore W759178093C134018914 @default.
- W759178093 hasConceptScore W759178093C149011108 @default.
- W759178093 hasConceptScore W759178093C153471976 @default.
- W759178093 hasConceptScore W759178093C180754005 @default.
- W759178093 hasConceptScore W759178093C2777704780 @default.
- W759178093 hasConceptScore W759178093C2778163477 @default.
- W759178093 hasConceptScore W759178093C2779982054 @default.
- W759178093 hasConceptScore W759178093C2780072125 @default.
- W759178093 hasConceptScore W759178093C2780541478 @default.
- W759178093 hasConceptScore W759178093C37002583 @default.
- W759178093 hasConceptScore W759178093C54355233 @default.
- W759178093 hasConceptScore W759178093C62746215 @default.
- W759178093 hasConceptScore W759178093C71924100 @default.
- W759178093 hasConceptScore W759178093C86803240 @default.
- W759178093 hasLocation W7591780931 @default.
- W759178093 hasOpenAccess W759178093 @default.
- W759178093 hasPrimaryLocation W7591780931 @default.
- W759178093 hasRelatedWork W1973478111 @default.
- W759178093 hasRelatedWork W1981610952 @default.
- W759178093 hasRelatedWork W1983618948 @default.
- W759178093 hasRelatedWork W2012678885 @default.
- W759178093 hasRelatedWork W2035360303 @default.
- W759178093 hasRelatedWork W2052117565 @default.
- W759178093 hasRelatedWork W2088968750 @default.
- W759178093 hasRelatedWork W2111938960 @default.
- W759178093 hasRelatedWork W2114013331 @default.
- W759178093 hasRelatedWork W2125757745 @default.
- W759178093 hasRelatedWork W2166256030 @default.
- W759178093 hasRelatedWork W2306289971 @default.
- W759178093 hasRelatedWork W2322358809 @default.
- W759178093 hasRelatedWork W2339504049 @default.
- W759178093 hasRelatedWork W2394896247 @default.
- W759178093 hasRelatedWork W2401530066 @default.
- W759178093 hasRelatedWork W2412001021 @default.
- W759178093 hasRelatedWork W2474980058 @default.
- W759178093 hasRelatedWork W87341050 @default.
- W759178093 hasRelatedWork W186907591 @default.
- W759178093 isParatext "false" @default.
- W759178093 isRetracted "false" @default.
- W759178093 magId "759178093" @default.
- W759178093 workType "book-chapter" @default.