FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W75932010> ?p ?o ?g. }

• W75932010 endingPage "605" @default.
• W75932010 startingPage "599" @default.
• W75932010 abstract "Patients with clinically palpable regional lymph node metastases (AJCC stage IIIB-C) carry a risk of relapse and death that approaches 70% at 5 years. Surgical excision with complete regional lymph node dissection is the cornerstone of management, followed by adjuvant therapy with high-dose interferon-α2b (HDI). Neoadjuvant therapy has been demonstrated to improve outcome in the management of patients of multiple different solid tumors. In patients with melanoma, the quality of the host immune response differs between those with earlier and those with more advanced disease settings. Host immune tolerance is now understood to impede the results of therapy for advanced disease, but may be less an issue for patients with microscopic high-risk operable disease, where the host may be more susceptible to immunologic interventions. Phase II studies have shown that neoadjuvant biochemotherapy has limited activity in melanoma patients with local-regional metastases, where chemotherapy may potentially antagonize or alter the effects of immunotherapeutic agents. Studies of neoadjuvant HDI therapy for high-risk melanoma patients with bulky regional stage IIIB-C lymphadenopathy are ongoing and preliminary results have shown unexpectedly high clinical and pathologic response rates, without increased morbidity. Through the design of neoadjuvant trials in which it is possible to obtain biopsy samples before and after therapy, a greater understanding of the dynamic interaction between tumors and the immune system is possible. This should lead to the identification of new targets for the treatment of melanoma and aid the development of new immunotherapies that may have greater specificity and less toxicity. This will simplify the evaluation of promising new combinations of agents with HDI to build on the clinical, immunologic, and molecular effect of this therapy for patients with melanoma." @default.
• W75932010 created "2016-06-24" @default.
• W75932010 creator A5007239425 @default.
• W75932010 creator A5020955148 @default.
• W75932010 date "2009-01-01" @default.
• W75932010 modified "2023-10-14" @default.
• W75932010 title "Neoadjuvant Approaches in Melanoma" @default.
• W75932010 cites W1828940258 @default.
• W75932010 cites W1908752382 @default.
• W75932010 cites W1951046932 @default.
• W75932010 cites W1955397179 @default.
• W75932010 cites W1975918912 @default.
• W75932010 cites W1988395666 @default.
• W75932010 cites W1998978540 @default.
• W75932010 cites W1999468766 @default.
• W75932010 cites W2001646586 @default.
• W75932010 cites W2047181127 @default.
• W75932010 cites W2066704699 @default.
• W75932010 cites W2070703301 @default.
• W75932010 cites W2078142473 @default.
• W75932010 cites W2078197336 @default.
• W75932010 cites W2107580116 @default.
• W75932010 cites W2112410464 @default.
• W75932010 cites W2118449798 @default.
• W75932010 cites W2119174775 @default.
• W75932010 cites W2120041024 @default.
• W75932010 cites W2121276929 @default.
• W75932010 cites W2122352172 @default.
• W75932010 cites W2131365547 @default.
• W75932010 cites W2147090478 @default.
• W75932010 cites W4323053376 @default.
• W75932010 doi "https://doi.org/10.1007/978-1-60327-087-8_50" @default.
• W75932010 hasPublicationYear "2009" @default.
• W75932010 type Work @default.
• W75932010 sameAs 75932010 @default.
• W75932010 citedByCount "0" @default.
• W75932010 crossrefType "book-chapter" @default.
• W75932010 hasAuthorship W75932010A5007239425 @default.
• W75932010 hasAuthorship W75932010A5020955148 @default.
• W75932010 hasConcept C121608353 @default.
• W75932010 hasConcept C126322002 @default.
• W75932010 hasConcept C141071460 @default.
• W75932010 hasConcept C143998085 @default.
• W75932010 hasConcept C146357865 @default.
• W75932010 hasConcept C151730666 @default.
• W75932010 hasConcept C203014093 @default.
• W75932010 hasConcept C2775934546 @default.
• W75932010 hasConcept C2776694085 @default.
• W75932010 hasConcept C2777658100 @default.
• W75932010 hasConcept C2777701055 @default.
• W75932010 hasConcept C2777863537 @default.
• W75932010 hasConcept C2777982462 @default.
• W75932010 hasConcept C2778292576 @default.
• W75932010 hasConcept C2779134260 @default.
• W75932010 hasConcept C2780212769 @default.
• W75932010 hasConcept C2780849966 @default.
• W75932010 hasConcept C502942594 @default.
• W75932010 hasConcept C530470458 @default.
• W75932010 hasConcept C71924100 @default.
• W75932010 hasConcept C86803240 @default.
• W75932010 hasConcept C8891405 @default.
• W75932010 hasConceptScore W75932010C121608353 @default.
• W75932010 hasConceptScore W75932010C126322002 @default.
• W75932010 hasConceptScore W75932010C141071460 @default.
• W75932010 hasConceptScore W75932010C143998085 @default.
• W75932010 hasConceptScore W75932010C146357865 @default.
• W75932010 hasConceptScore W75932010C151730666 @default.
• W75932010 hasConceptScore W75932010C203014093 @default.
• W75932010 hasConceptScore W75932010C2775934546 @default.
• W75932010 hasConceptScore W75932010C2776694085 @default.
• W75932010 hasConceptScore W75932010C2777658100 @default.
• W75932010 hasConceptScore W75932010C2777701055 @default.
• W75932010 hasConceptScore W75932010C2777863537 @default.
• W75932010 hasConceptScore W75932010C2777982462 @default.
• W75932010 hasConceptScore W75932010C2778292576 @default.
• W75932010 hasConceptScore W75932010C2779134260 @default.
• W75932010 hasConceptScore W75932010C2780212769 @default.
• W75932010 hasConceptScore W75932010C2780849966 @default.
• W75932010 hasConceptScore W75932010C502942594 @default.
• W75932010 hasConceptScore W75932010C530470458 @default.
• W75932010 hasConceptScore W75932010C71924100 @default.
• W75932010 hasConceptScore W75932010C86803240 @default.
• W75932010 hasConceptScore W75932010C8891405 @default.
• W75932010 hasLocation W759320101 @default.
• W75932010 hasOpenAccess W75932010 @default.
• W75932010 hasPrimaryLocation W759320101 @default.
• W75932010 hasRelatedWork W1581661267 @default.
• W75932010 hasRelatedWork W1968180642 @default.
• W75932010 hasRelatedWork W2011359933 @default.
• W75932010 hasRelatedWork W2011392965 @default.
• W75932010 hasRelatedWork W2094050036 @default.
• W75932010 hasRelatedWork W2106376036 @default.
• W75932010 hasRelatedWork W2419557209 @default.
• W75932010 hasRelatedWork W2462127705 @default.
• W75932010 hasRelatedWork W3095465973 @default.
• W75932010 hasRelatedWork W4312352277 @default.
• W75932010 isParatext "false" @default.
• W75932010 isRetracted "false" @default.

• next