Matches in SemOpenAlex for { <https://semopenalex.org/work/W75981909> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W75981909 endingPage "759" @default.
- W75981909 startingPage "755" @default.
- W75981909 abstract "The nuclear enzyme DNA topoisomerase II (topo II) is the target of important antitumor agents such as etoposide. Recent work has classified topo II targeting drugs into either topo II poisons that act by stabilizing enzyme-DNA cleavable complexes leading to DNA breaks, or topo II catalytic inhibitors that act at stages in the catalytic cycle of the enzyme where both DNA strands are intact and, therefore, do not cause DNA breaks. Accordingly, catalytic inhibitors are known to abrogate DNA damage and cytotoxicity caused by topo II poisons. In this commentary, we have focused on the possibilities of enabling high-dose therapy with the topo II poison etoposide by protection of normal tissue with catalytic inhibitors, analogous to folinic acid rescue in high-dose methotrexate treatment. Thus, we have demonstrated recently that ( + )-1,2-bis(3,5-dioxopiperazinyl-1-yl) propane (ICRF-187) enabled a 3- to 4-fold dose escalation of etoposide in mice. Two high-dose etoposide models are described, namely use of the weak base chloroquine in tumors with acidic extracellular pH and targeting of CNS tumors with protection of normal tissue by the bisdioxopiperazine ICRF-187. In conclusion, high supralethal doses of topo II poisons in combination with catalytic inhibitor protection form a new strategy to improve the antitumor selectivity of etoposide and other topo II poisons. Such an approach may be used to overcome problems with drug resistance and drug penetration." @default.
- W75981909 created "2016-06-24" @default.
- W75981909 creator A5065012596 @default.
- W75981909 creator A5080295504 @default.
- W75981909 date "1997-10-01" @default.
- W75981909 modified "2023-09-27" @default.
- W75981909 title "DNA topoisomerase II rescue by catalytic inhibitors" @default.
- W75981909 cites W1533405440 @default.
- W75981909 cites W1568313491 @default.
- W75981909 cites W1909111805 @default.
- W75981909 cites W2018347425 @default.
- W75981909 cites W2018468886 @default.
- W75981909 cites W2031066426 @default.
- W75981909 cites W2032010436 @default.
- W75981909 cites W2042367294 @default.
- W75981909 cites W2050888120 @default.
- W75981909 cites W2069256784 @default.
- W75981909 cites W2071302385 @default.
- W75981909 cites W2083262002 @default.
- W75981909 cites W2085075058 @default.
- W75981909 cites W2103489107 @default.
- W75981909 cites W2128175002 @default.
- W75981909 cites W4236530034 @default.
- W75981909 doi "https://doi.org/10.1016/s0006-2952(97)00116-0" @default.
- W75981909 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9353129" @default.
- W75981909 hasPublicationYear "1997" @default.
- W75981909 type Work @default.
- W75981909 sameAs 75981909 @default.
- W75981909 citedByCount "56" @default.
- W75981909 countsByYear W759819092013 @default.
- W75981909 countsByYear W759819092014 @default.
- W75981909 countsByYear W759819092015 @default.
- W75981909 countsByYear W759819092017 @default.
- W75981909 countsByYear W759819092018 @default.
- W75981909 countsByYear W759819092019 @default.
- W75981909 countsByYear W759819092021 @default.
- W75981909 crossrefType "journal-article" @default.
- W75981909 hasAuthorship W75981909A5065012596 @default.
- W75981909 hasAuthorship W75981909A5080295504 @default.
- W75981909 hasConcept C143425029 @default.
- W75981909 hasConcept C147897179 @default.
- W75981909 hasConcept C181199279 @default.
- W75981909 hasConcept C185592680 @default.
- W75981909 hasConcept C2776694085 @default.
- W75981909 hasConcept C2778119113 @default.
- W75981909 hasConcept C2778616834 @default.
- W75981909 hasConcept C54355233 @default.
- W75981909 hasConcept C552990157 @default.
- W75981909 hasConcept C55493867 @default.
- W75981909 hasConcept C86803240 @default.
- W75981909 hasConcept C98274493 @default.
- W75981909 hasConceptScore W75981909C143425029 @default.
- W75981909 hasConceptScore W75981909C147897179 @default.
- W75981909 hasConceptScore W75981909C181199279 @default.
- W75981909 hasConceptScore W75981909C185592680 @default.
- W75981909 hasConceptScore W75981909C2776694085 @default.
- W75981909 hasConceptScore W75981909C2778119113 @default.
- W75981909 hasConceptScore W75981909C2778616834 @default.
- W75981909 hasConceptScore W75981909C54355233 @default.
- W75981909 hasConceptScore W75981909C552990157 @default.
- W75981909 hasConceptScore W75981909C55493867 @default.
- W75981909 hasConceptScore W75981909C86803240 @default.
- W75981909 hasConceptScore W75981909C98274493 @default.
- W75981909 hasIssue "7" @default.
- W75981909 hasLocation W759819091 @default.
- W75981909 hasLocation W759819092 @default.
- W75981909 hasOpenAccess W75981909 @default.
- W75981909 hasPrimaryLocation W759819091 @default.
- W75981909 hasRelatedWork W1974397158 @default.
- W75981909 hasRelatedWork W1980092410 @default.
- W75981909 hasRelatedWork W1995556774 @default.
- W75981909 hasRelatedWork W1995824574 @default.
- W75981909 hasRelatedWork W2050101539 @default.
- W75981909 hasRelatedWork W2252959597 @default.
- W75981909 hasRelatedWork W2344056970 @default.
- W75981909 hasRelatedWork W2396796971 @default.
- W75981909 hasRelatedWork W2478496593 @default.
- W75981909 hasRelatedWork W2736033779 @default.
- W75981909 hasVolume "54" @default.
- W75981909 isParatext "false" @default.
- W75981909 isRetracted "false" @default.
- W75981909 magId "75981909" @default.
- W75981909 workType "article" @default.