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- W759916237 abstract "Research on termination of the replication cycle and the terminus region was prompted by the discovery of bidirectional replication of the Escherichia coli chromosome. Studies of the Tus-Ter system and the terminus region had other fruitful consequences, since they led to the recognition of phenomena important in the cell cycle, which are restricted to the terminus region by features of the global organization of the bacterial nucleoid. This chapter describes one's current understanding of the features of the terminus region. The core of this chapter deals with resolution of chromosome dimers by the dif-XerCD/FtsK system and its regional control. Other aspects, such as the organization in nondivisible zones (NDZ), local hyper recombination, and evolution of terminus sequences, are also presented in this chapter. Stress is placed the role of the terminus in the ultimate operations of the replication cycle and the postreplicative processing of sister chromosomes. The first evidence for bipolarization of the terminus region was provided by the distribution of the Ter pause sites. According to the author, the arrangement of polar pause sites on the chromosome, which forces replication to terminate in the center of the terminus macrodomain near dif, facilitates temporal harmony between end of replication and triggering of events which, like movements of the TER domains away from the septal plane, involve the chromosome polarization centered on dif. The function of the terminus region about which the most is known is the resolution of circular dimer chromosomes." @default.
- W759916237 created "2016-06-24" @default.
- W759916237 creator A5015700197 @default.
- W759916237 creator A5070062221 @default.
- W759916237 creator A5076207145 @default.
- W759916237 date "2014-04-30" @default.
- W759916237 modified "2023-10-18" @default.
- W759916237 title "The Terminus Region of the<i>Escherichia coli</i>Chromosome, or, All's Well That Ends Well" @default.
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