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• W75992169 startingPage "27" @default.
• W75992169 abstract "L-selectin, which is expressed by the majority of leukocytes, plays a pivotal role in the generation of rapid and efficient immune responses by mediating the interaction of circulating leukocytes with the vascular endothelium. Specifically, L-selectin functions to mediate the attachment of leukocytes to the vascular wall at sites of inflammation and the attachment of lymphocytes to specialized post-capillary venules termed “high endothelial venules” (HEV) located within secondary lymphoid tissues. This initial adhesive event termed “capture” or “tethering” occurs through selective interaction of L-selectin with its appropriately displayed ligand(s). While this adhesive function has largely defined L-selectin, it is now clear that L-selectin functions in a highly complex manner during leukocyte recruitment. For example, L-selectin has been demonstrated to function cooperatively and synergistically with other adhesion molecules under in vivo inflammatory conditions to mediate optimal leukocyte recruitment [1, 2]. In addition, L-selectin function can be positively and negatively regulated following leukocyte activation, both of which significantly impact leukocyte recruitment. Specifically, L-selectin ligand binding activity is transiently increased following leukocyte activation [3] followed by its rapid endoproteolytic cleavage or “shedding” from the leukocyte surface [4]. Interestingly, the generation of this soluble form of L-selectin (sL-selectin) that retains functional activity may serve to dampen inflammatory responses by competing with cell-surface L-selectin for ligand binding [5, 6]." @default.
• W75992169 created "2016-06-24" @default.
• W75992169 creator A5016161559 @default.
• W75992169 creator A5035210187 @default.
• W75992169 creator A5085514872 @default.
• W75992169 creator A5086156457 @default.
• W75992169 creator A5089029249 @default.
• W75992169 date "2007-01-01" @default.
• W75992169 modified "2023-09-25" @default.
• W75992169 title "L-selectin-mediated leukocyte adhesion and migration" @default.
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