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- W76005577 abstract "In previous study showed that fractions of n-Hexane, ethylacetate (EtOAc), and butanol (BuOH) from HS crude extract were evaluated for their wound healing activity by using in vivo ulcer models. Although n-Hexane and EtOAc fractions promote wound healing in mice with ulcer, the BuOH fraction exhibited the most potent wound healing activity and the wound area score significantly decreased after treatment of BuOH fraction. In present study, BuOH fraction from HS crude extract was evaluated for their wound healing effect by using in vitro acute inflammation model. The BuOH fraction stimulated peritoneal cells and RAW264.7 cell to increase the production of nitric oxide (NO), IL-6, IL-10, VEGF and TNF-a. The fraction inhibited the LPS-induced production of NO, VEGF, and TGF-β at a dose-dependent manner. It also activated mouse keratinocyte to increase the production of IL-6 and TNF-a. The mRNA expression and activation of IL-1β and TLR2 were increased by BuOH fraction, while LPS-induced IL-1β and TLR2 expression were decreased. The mechanism that the HS helps to promote healing by inflammation is possibly associated with the production of TNF-a as well as the secretion of VEGF, IL-6, IL-10 and TLR2, which were involved to mediate innate immune responses to a variety of stimuli." @default.
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- W76005577 date "2013-09-01" @default.
- W76005577 modified "2023-10-17" @default.
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- W76005577 doi "https://doi.org/10.1016/j.cyto.2013.06.162" @default.
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