Matches in SemOpenAlex for { <https://semopenalex.org/work/W760132908> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W760132908 abstract "Follicular lymphomas form a distinctive group of malignant lymphomas with a characteristic course of ever relapsing disease, that ultimately - after histologic transformation - causes the patients' death years after diagnosis. Treatment of such patients remains a dilemma. Initially, a wait and see policy is allowed in an asymptomatic patient. Once therapy is indicated, temporal responses are seen to diverse treatment modalities and regimens. Unfortunately, in general, only prolongation of progression-free but not overall survival is achieved by several therapies. An exception to this rule seems to be the intensification of treatment to myelo-ablative therapy followed by allogeneic stem cell transplantation. In contrast to the lack of improvement of clinical outcome of patients with follicular lymphoma, diagnostics have in fact greatly gained sensitivity during the past decades. With the introduction of real-time polymerase chain reaction in molecular diagnostics, cells carrying the chromosomal translocation t(14;18), characteristic for follicular lymphoma, can be quantitated very sensitively. The present thesis focuses on the potential role of molecular diagnostics, i.e. the quantitative monitoring of t(14;18) positive cells, in the treatment of follicular lymphoma patients. Analysis of circulating lymphoma cells might be valuable in early evaluation of the efficacy of (new) therapies, because it may take years before clinical observations can show any survival benefit, due to the indolent course of disease. Until now questions remain on the clinical significance of the presence, and if so in what quantity, of circulating lymphoma cells. Studies presented here try to rationalise the use of molecular diagnostics in follicular lymphoma" @default.
- W760132908 created "2016-06-24" @default.
- W760132908 creator A5022781813 @default.
- W760132908 date "2002-01-01" @default.
- W760132908 modified "2023-09-26" @default.
- W760132908 title "Treatment of patients with follicular lymphoma, a role for molecular diagnostics?" @default.
- W760132908 hasPublicationYear "2002" @default.
- W760132908 type Work @default.
- W760132908 sameAs 760132908 @default.
- W760132908 citedByCount "0" @default.
- W760132908 crossrefType "dissertation" @default.
- W760132908 hasAuthorship W760132908A5022781813 @default.
- W760132908 hasConcept C126322002 @default.
- W760132908 hasConcept C142724271 @default.
- W760132908 hasConcept C143998085 @default.
- W760132908 hasConcept C179786068 @default.
- W760132908 hasConcept C203014093 @default.
- W760132908 hasConcept C2777058707 @default.
- W760132908 hasConcept C2777910003 @default.
- W760132908 hasConcept C2779134260 @default.
- W760132908 hasConcept C2779338263 @default.
- W760132908 hasConcept C60644358 @default.
- W760132908 hasConcept C71924100 @default.
- W760132908 hasConcept C86803240 @default.
- W760132908 hasConceptScore W760132908C126322002 @default.
- W760132908 hasConceptScore W760132908C142724271 @default.
- W760132908 hasConceptScore W760132908C143998085 @default.
- W760132908 hasConceptScore W760132908C179786068 @default.
- W760132908 hasConceptScore W760132908C203014093 @default.
- W760132908 hasConceptScore W760132908C2777058707 @default.
- W760132908 hasConceptScore W760132908C2777910003 @default.
- W760132908 hasConceptScore W760132908C2779134260 @default.
- W760132908 hasConceptScore W760132908C2779338263 @default.
- W760132908 hasConceptScore W760132908C60644358 @default.
- W760132908 hasConceptScore W760132908C71924100 @default.
- W760132908 hasConceptScore W760132908C86803240 @default.
- W760132908 hasLocation W7601329081 @default.
- W760132908 hasOpenAccess W760132908 @default.
- W760132908 hasPrimaryLocation W7601329081 @default.
- W760132908 hasRelatedWork W122188935 @default.
- W760132908 hasRelatedWork W1479541392 @default.
- W760132908 hasRelatedWork W1973773204 @default.
- W760132908 hasRelatedWork W1976153015 @default.
- W760132908 hasRelatedWork W1976423675 @default.
- W760132908 hasRelatedWork W1982666644 @default.
- W760132908 hasRelatedWork W2015954452 @default.
- W760132908 hasRelatedWork W2138193757 @default.
- W760132908 hasRelatedWork W2165094600 @default.
- W760132908 hasRelatedWork W2313363918 @default.
- W760132908 hasRelatedWork W2404183004 @default.
- W760132908 hasRelatedWork W2411278983 @default.
- W760132908 hasRelatedWork W2464684930 @default.
- W760132908 hasRelatedWork W2795353505 @default.
- W760132908 hasRelatedWork W2978587128 @default.
- W760132908 hasRelatedWork W2991421152 @default.
- W760132908 hasRelatedWork W3032009767 @default.
- W760132908 hasRelatedWork W3087550239 @default.
- W760132908 hasRelatedWork W65254357 @default.
- W760132908 hasRelatedWork W78817974 @default.
- W760132908 isParatext "false" @default.
- W760132908 isRetracted "false" @default.
- W760132908 magId "760132908" @default.
- W760132908 workType "dissertation" @default.