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- W760667721 abstract "In this study, a novel analytical method has been developed for the rapid determination of L-carnitine in human plasma using electrospray ionization tandem mass spectrometry. Free carnitine (FC) was analyzed after extraction with 80% methanol and total carnitine (TC) was analyzed after hydrolysis and extraction. Acyl carnitine (AC) was subtracted FC from TC. Analytical methods used multiple reaction monitoring (MRM) scan modes. A correlation coefficient of linear regression (r 2 ) was 0.9995, recovery was 97%, reproducibility was less than 10%, and limit of detection (LOD) was 0.0016 μmol/L. This method reduced sample preparation time and showed high resolution and good reproducibility compared to that with liquid chromatographic methods. Normal control showed AC" @default.
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- W760667721 date "2005-01-01" @default.
- W760667721 modified "2023-09-24" @default.
- W760667721 title "Quantitation of L-carnitine in plasma by electrospray ionization tandem mass spectrometry" @default.
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