Matches in SemOpenAlex for { <https://semopenalex.org/work/W76176795> ?p ?o ?g. }
- W76176795 abstract "After the discovery of parathyroid hormone-related protein (PTHrP) as the cause of the hypercalcemia of malignancy, it was found to be distributed widely in tissues, with many physiologic and pathologic roles as a paracrine effector. The involvement of PTHrP in cancer extended its contribution to include the ability of cancer cells to promote bone resorption and metastasize. PTHrP and PTH appear to have arisen from a common ancestral gene, but it is uncertain which came first. Both PTH and PTHrP are tracked in evolutionary time to fish, with evidence of both ligands in cartilagenous fish. The PTHrP gene ( PTHLH ), with three promoters in the human gene and nine exons, has many simple variations, but the known structural and regulatory features of the gene are grossly conserved across multiple species. In their structural organizations, the chicken, mouse, and rat PTHLH genes share substantial homology with the human gene, although the mouse and rat genes are considerably simpler. Thus, the greater complexity of the human PTHLH gene appears to be a late evolutionary event. PTHrP has been found to have multiple activities within the protein sequence, beyond the amino-terminal domain, which shares with PTH action upon a common receptor. These additional domains include a nuclear localizing sequence, a specific nuclear transport system, and other domains associated with multiple biologic activities. The nuclear role(s), the susceptibility of PTHrP to endoproteolysis, together with the lability of PTHrP mRNA and the multiple splice forms, may be the result of evolutionary pressures that equip PTHrP to function as a paracrine agent, as it does in many tissues." @default.
- W76176795 created "2016-06-24" @default.
- W76176795 creator A5042599014 @default.
- W76176795 creator A5050072511 @default.
- W76176795 creator A5069853428 @default.
- W76176795 date "2015-01-01" @default.
- W76176795 modified "2023-09-24" @default.
- W76176795 title "Parathyroid Hormone-related Protein" @default.
- W76176795 cites W118372881 @default.
- W76176795 cites W1494347068 @default.
- W76176795 cites W1512392500 @default.
- W76176795 cites W1517070102 @default.
- W76176795 cites W1530747537 @default.
- W76176795 cites W1554508620 @default.
- W76176795 cites W1559616885 @default.
- W76176795 cites W1589662186 @default.
- W76176795 cites W1595268720 @default.
- W76176795 cites W1611596466 @default.
- W76176795 cites W1757679215 @default.
- W76176795 cites W1797037641 @default.
- W76176795 cites W1826494689 @default.
- W76176795 cites W1879911117 @default.
- W76176795 cites W1963933110 @default.
- W76176795 cites W1964682122 @default.
- W76176795 cites W1967738780 @default.
- W76176795 cites W1967780379 @default.
- W76176795 cites W1968093456 @default.
- W76176795 cites W1968109929 @default.
- W76176795 cites W1969749569 @default.
- W76176795 cites W1971185985 @default.
- W76176795 cites W1971692212 @default.
- W76176795 cites W1972983311 @default.
- W76176795 cites W1973466133 @default.
- W76176795 cites W1973857041 @default.
- W76176795 cites W1973874267 @default.
- W76176795 cites W1976243900 @default.
- W76176795 cites W1977031433 @default.
- W76176795 cites W1979813907 @default.
- W76176795 cites W1981269604 @default.
- W76176795 cites W1981606245 @default.
- W76176795 cites W1982150046 @default.
- W76176795 cites W1982875955 @default.
- W76176795 cites W1982980731 @default.
- W76176795 cites W1983950276 @default.
- W76176795 cites W1985738984 @default.
- W76176795 cites W1985821780 @default.
- W76176795 cites W1986713541 @default.
- W76176795 cites W1990490334 @default.
- W76176795 cites W1991424506 @default.
- W76176795 cites W1991579469 @default.
- W76176795 cites W1992442285 @default.
- W76176795 cites W1992703428 @default.
- W76176795 cites W1992880731 @default.
- W76176795 cites W1993159515 @default.
- W76176795 cites W1995499476 @default.
- W76176795 cites W1997966520 @default.
- W76176795 cites W1998858703 @default.
- W76176795 cites W1999806767 @default.
- W76176795 cites W1999856310 @default.
- W76176795 cites W2002339005 @default.
- W76176795 cites W2004937148 @default.
- W76176795 cites W2006412044 @default.
- W76176795 cites W2007091379 @default.
- W76176795 cites W2008306523 @default.
- W76176795 cites W2008361272 @default.
- W76176795 cites W2009190733 @default.
- W76176795 cites W2009935171 @default.
- W76176795 cites W2010119292 @default.
- W76176795 cites W2010264145 @default.
- W76176795 cites W2011911552 @default.
- W76176795 cites W2014198576 @default.
- W76176795 cites W2014619010 @default.
- W76176795 cites W2015001618 @default.
- W76176795 cites W2017211434 @default.
- W76176795 cites W2018725923 @default.
- W76176795 cites W2020644208 @default.
- W76176795 cites W2020814497 @default.
- W76176795 cites W2021706227 @default.
- W76176795 cites W2023333174 @default.
- W76176795 cites W2024975417 @default.
- W76176795 cites W2025650956 @default.
- W76176795 cites W2025979167 @default.
- W76176795 cites W2026787670 @default.
- W76176795 cites W2028087033 @default.
- W76176795 cites W2029049247 @default.
- W76176795 cites W2029190746 @default.
- W76176795 cites W2030047242 @default.
- W76176795 cites W2033691415 @default.
- W76176795 cites W2033841429 @default.
- W76176795 cites W2034419606 @default.
- W76176795 cites W2034637577 @default.
- W76176795 cites W2036775128 @default.
- W76176795 cites W2037038111 @default.
- W76176795 cites W2037735580 @default.
- W76176795 cites W2039262401 @default.
- W76176795 cites W2039879661 @default.
- W76176795 cites W2040756948 @default.
- W76176795 cites W2041509376 @default.
- W76176795 cites W2042567846 @default.
- W76176795 cites W2043099061 @default.