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- W761864540 abstract "Addition of 30% propylene glycol was required to maintain sink condition in the evaluation of percutaneous absorption of estradiol and norethindrone acetate. The permeability of estradiol was higher in silicone and SIS adhesives. However, estradiol was crystallized in silicone, SIS, and SBS adhesive matrix. The permeability ratio of estradiol or norethindrone acetate from acrylic pressure sensitive adhesives varied widely depending on the functional group of the acrylic adhesives. PEO grafting to acrylic adhesive seemed to change physicochemical property of acrylic adhesive and increased the permeability of estradiol and norethindrone acetate significantly. On the contrary, highly cross-linked enhancer compatible acrylic adhesive decreased the permeability of both estradiol and norethindrone acetate. 20 provided the highest enhancing effect on the permeability of both estradiol and norethindrone acetate followed by oleic acid and EP40. The permeability of the drugs from the developed system was comparable to that from commercial , although significantly lower amount of estradiol and norethindrone acetate were loaded in the developed system." @default.
- W761864540 created "2016-06-24" @default.
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- W761864540 date "2005-06-20" @default.
- W761864540 modified "2023-09-27" @default.
- W761864540 title "Transdermal Delivery of Estradiol and Norethindrone Acetate: Effect of Vehicles and Pressure Sensitive Adhesive Matrix" @default.
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- W761864540 doi "https://doi.org/10.4333/kps.2005.35.3.173" @default.
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