FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W76193478> ?p ?o ?g. }

• W76193478 endingPage "731" @default.
• W76193478 startingPage "641" @default.
• W76193478 abstract "Overnutrition manifested by obesity has emerged as a major health problem in affluent countries. In spite of increased interest in fitness, obesity is on the increase in the United States. This is particularly so among children and adolescents. Although obesity is associated with many risk factors for diseases, the mechanisms whereby it enhances disease risk are not fully understood. Such an understanding is needed to develop strategies for management of these conditions. In this report we suggest that overnutrition produces clinical diseases only in individuals who already possess a metabolic weakness or defect in a given system. In the absence of such underlying defects, overnutrition, or obesity, is well tolerated. One of the most common consequences of obesity is dyslipidemia, that is, elevations of very low-density lipoprotein (VLDL) triglycerides and low-density lipoprotein (LDL) cholesterol and low concentrations of high-density lipoprotein (HDL) cholesterol. The major effect of overnutrition on lipoprotein metabolism is to stimulate the production of VLDL. For patients who have an underlying defect in lypolysis of VLDL triglycerides, hypertriglyceridemia will develop in the obese state. For those who have defective clearance of LDL, obesity will accentuate hypercholesterolemia. Both of these effects can be explained by overproduction of VLDL, due to obesity, combined with a genetic defect in clearance of VLDL or LDL. The mechanism whereby obesity causes a lowering of HDL cholesterol is uncertain, although it could enhance removal of HDL by an excess of adipose tissue. Another disease associated with obesity is cholesterol gallstones. The presence of obesity more than doubles the risk for gallstones. Two underlying factors increase the danger for gallstones: a deficiency of hepatic secretion of bile acids and a tendency for formation of cholesterol crystals in bile. Overnutrition promotes the synthesis of whole-body cholesterol, and the only route for excretion of this excess cholesterol is through the biliary tree.(ABSTRACT TRUNCATED AT 400 WORDS)" @default.
• W76193478 created "2016-06-24" @default.
• W76193478 creator A5022148811 @default.
• W76193478 creator A5056794714 @default.
• W76193478 date "1990-12-01" @default.
• W76193478 modified "2023-10-01" @default.
• W76193478 title "Metabolic and health complications of obesity." @default.
• W76193478 cites W112889243 @default.
• W76193478 cites W123433672 @default.
• W76193478 cites W1277818 @default.
• W76193478 cites W1483655665 @default.
• W76193478 cites W1484963795 @default.
• W76193478 cites W1485806819 @default.
• W76193478 cites W1490037398 @default.
• W76193478 cites W149198324 @default.
• W76193478 cites W1503096668 @default.
• W76193478 cites W1505960802 @default.
• W76193478 cites W1513856053 @default.
• W76193478 cites W1519002109 @default.
• W76193478 cites W1528809057 @default.
• W76193478 cites W1531062343 @default.
• W76193478 cites W1532924657 @default.
• W76193478 cites W1543763691 @default.
• W76193478 cites W1545507706 @default.
• W76193478 cites W1549023926 @default.
• W76193478 cites W1552709412 @default.
• W76193478 cites W1626664700 @default.
• W76193478 cites W1765750524 @default.
• W76193478 cites W1823466767 @default.
• W76193478 cites W1833877467 @default.
• W76193478 cites W1854257819 @default.
• W76193478 cites W1879297302 @default.
• W76193478 cites W1891830453 @default.
• W76193478 cites W1909180518 @default.
• W76193478 cites W1922826700 @default.
• W76193478 cites W1926489991 @default.
• W76193478 cites W1931225401 @default.
• W76193478 cites W1935534922 @default.
• W76193478 cites W1944351928 @default.
• W76193478 cites W1946178666 @default.
• W76193478 cites W1960724357 @default.
• W76193478 cites W1963847700 @default.
• W76193478 cites W1964518868 @default.
• W76193478 cites W1964891036 @default.
• W76193478 cites W1965431821 @default.
• W76193478 cites W1966415450 @default.
• W76193478 cites W1968413141 @default.
• W76193478 cites W1968426538 @default.
• W76193478 cites W1969301909 @default.
• W76193478 cites W1969480413 @default.
• W76193478 cites W1969483062 @default.
• W76193478 cites W1969956958 @default.
• W76193478 cites W1970315757 @default.
• W76193478 cites W1974344003 @default.
• W76193478 cites W1976560133 @default.
• W76193478 cites W1976987936 @default.
• W76193478 cites W1977523857 @default.
• W76193478 cites W1979721410 @default.
• W76193478 cites W1980041972 @default.
• W76193478 cites W1982143871 @default.
• W76193478 cites W1984143520 @default.
• W76193478 cites W1986207908 @default.
• W76193478 cites W1986707185 @default.
• W76193478 cites W1989061680 @default.
• W76193478 cites W1995392366 @default.
• W76193478 cites W1999188473 @default.
• W76193478 cites W1999953580 @default.
• W76193478 cites W2001766548 @default.
• W76193478 cites W2002044281 @default.
• W76193478 cites W2003423742 @default.
• W76193478 cites W2006619997 @default.
• W76193478 cites W2007569477 @default.
• W76193478 cites W2008251449 @default.
• W76193478 cites W2009470200 @default.
• W76193478 cites W2009720062 @default.
• W76193478 cites W2010497181 @default.
• W76193478 cites W201098161 @default.
• W76193478 cites W2011397631 @default.
• W76193478 cites W2011493444 @default.
• W76193478 cites W2013126351 @default.
• W76193478 cites W2013161169 @default.
• W76193478 cites W2014420470 @default.
• W76193478 cites W2015416939 @default.
• W76193478 cites W2017864300 @default.
• W76193478 cites W2018033196 @default.
• W76193478 cites W2018280313 @default.
• W76193478 cites W2022822994 @default.
• W76193478 cites W2023850224 @default.
• W76193478 cites W2024753390 @default.
• W76193478 cites W2026068335 @default.
• W76193478 cites W2027287053 @default.
• W76193478 cites W2027493645 @default.
• W76193478 cites W2028325182 @default.
• W76193478 cites W2028668293 @default.
• W76193478 cites W2028895130 @default.
• W76193478 cites W2031988119 @default.
• W76193478 cites W2034201007 @default.
• W76193478 cites W2034515512 @default.

• next