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- W762290985 abstract "Panax Notoginseng Saponins (PNS), extracted from the roots of the common TCM Panax notoginseng (Burk.) F.H.Chen, consist of notoginsenoside R 1 , ginsenoside Rg 1 , Re, Rb 1 , Rd and many other chemicals which haven’t been identified. Due to its popular pharmacological effects, it is of importance to control the quality. This study combines design of experiments and design space methodology to optimize the HPLC separation of PNS. Three common chromatographic parameters (i.e. the temperature, the initial proportion of acetonitrile and the gradient slope) were selected to construct a Box-Behnken design which consisted of 17 experiments. A quadratic model that was built from the experimental result was used to construct the design space. The optimal separation was predicted at temperature 20°C;, with a gradient starting at 15% of acetonitrile and a gradient slope of 0.55%/min. Accuracy profile approach was employed to validate the established HPLC method. The results clearly showed that quality by design methodology could be effectively applied to optimize the HPLC chromatographic conditions for the analysis of PNS." @default.
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- W762290985 date "2015-06-26" @default.
- W762290985 modified "2023-10-17" @default.
- W762290985 title "Application of Design of Experiment and Design Space (DOE-DS) Methodology for the HPLC Separation of Panax Notoginseng Saponins" @default.
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- W762290985 doi "https://doi.org/10.2174/1874123101509010047" @default.
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